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    Mrpl48 mitochondrial ribosomal protein L48 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293149, updated on 9-Dec-2024

    Summary

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    Symbol
    Mrpl48provided by RGD
    Full Name
    mitochondrial ribosomal protein L48provided by RGD
    Primary source
    RGD:1307576
    See related
    EnsemblRapid:ENSRNOG00000018042 AllianceGenome:RGD:1307576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Orthologous to human MRPL48 (mitochondrial ribosomal protein L48). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 292.2), Muscle (RPKM 246.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl48 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164308787..164370034, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154896663..154939285, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165563788..165606375, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691200 Neighboring gene uncharacterized LOC120099893 Neighboring gene uncharacterized LOC120099894 Neighboring gene cytochrome c oxidase assembly factor 4 homolog Neighboring gene small nucleolar RNA SNORA4 Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. Haque ME, et al. J Biol Chem, 2010 Sep 3. PMID 20601428, Free PMC Article
    2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL48
    Names
    39S ribosomal protein L48, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106282.1 → NP_001099752.1  large ribosomal subunit protein mL48 isoform 2

      See identical proteins and their annotated locations for NP_001099752.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6APR3, A6I6P8, D3ZDX7
      Related
      ENSRNOP00000096505.2, ENSRNOT00000097667.2
      Conserved Domains (2) summary
      smart00487
      Location:132 → 194
      DEXDc; DEAD-like helicases superfamily
      pfam00338
      Location:91 → 185
      Ribosomal_S10; Ribosomal protein S10p/S20e

    2. NM_001428992.1 → NP_001415921.1  large ribosomal subunit protein mL48 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6APR3

    3. NM_001428993.1 → NP_001415922.1  large ribosomal subunit protein mL48 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164308787..164370034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285143.1 → XP_063141213.1  large ribosomal subunit protein mL48 isoform X1

      Related
      ENSRNOP00000104124.1, ENSRNOT00000140762.1

    2. XM_039106102.2 → XP_038962030.1  large ribosomal subunit protein mL48 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9S3, A6I6P9
      Conserved Domains (1) summary
      pfam00338
      Location:1 → 87
      Ribosomal_S10; Ribosomal protein S10p/S20e

    3. XM_039106100.2 → XP_038962028.1  large ribosomal subunit protein mL48 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9S3, A6I6P9
      Conserved Domains (1) summary
      pfam00338
      Location:1 → 87
      Ribosomal_S10; Ribosomal protein S10p/S20e

    4. XM_063285156.1 → XP_063141226.1  large ribosomal subunit protein mL48 isoform X3

    5. XM_063285146.1 → XP_063141216.1  large ribosomal subunit protein mL48 isoform X2

    RNA

    1. XR_010065073.1 RNA Sequence

    2. XR_010065072.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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