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    Amdhd2 amidohydrolase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amdhd2provided by RGD
    Official Full Name
    amidohydrolase domain containing 2provided by RGD
    Primary source
    RGD:1304601
    See related
    EnsemblRapid:ENSRNOG00000006460 AllianceGenome:RGD:1304601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304601
    Summary
    Predicted to enable N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process and negative regulation of UDP-N-acetylglucosamine biosynthetic process. Orthologous to human AMDHD2 (amidohydrolase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 86.9), Spleen (RPKM 48.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amdhd2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13692136..13700632, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13187579..13196148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13528400..13536949, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 5 Neighboring gene 3-phosphoinositide dependent protein kinase-1 Neighboring gene ATPase H+ transporting V0 subunit C Neighboring gene TBC1 domain family, member 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
    2. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109150

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables N-acetylgalactosamine-6-phosphate deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylglucosamine-6-phosphate deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglucosamine-6-phosphate deacetylase
    Names
    amidohydrolase domain-containing protein 2
    glcNAc 6-P deacetylase
    putative N-acetylglucosamine-6-phosphate deacetylase
    NP_001020161.2
    XP_038941785.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024990.2 → NP_001020161.2  N-acetylglucosamine-6-phosphate deacetylase

      See identical proteins and their annotated locations for NP_001020161.2

      Status: VALIDATED

      Source sequence(s)
      BC091278, CO388545
      UniProtKB/Swiss-Prot
      Q5BJY6
      UniProtKB/TrEMBL
      A0A8I6A4U1, A6HCQ3
      Related
      ENSRNOP00000008537.7, ENSRNOT00000008537.7
      Conserved Domains (1) summary
      cd00854
      Location:13 → 398
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13692136..13700632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085857.2 → XP_038941785.1  N-acetylglucosamine-6-phosphate deacetylase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4U1, A0A8L2Q3B7
      Conserved Domains (1) summary
      cd00854
      Location:13 → 362
      NagA; N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJY6.2 GenPept UniProtKB/Swiss-Prot:Q5BJY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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