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    Cbr4 carbonyl reductase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 359725, updated on 9-Dec-2024

    Summary

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    Symbol
    Cbr4provided by RGD
    Full Name
    carbonyl reductase 4provided by RGD
    Primary source
    RGD:727826
    See related
    AllianceGenome:RGD:727826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in several processes, including daunorubicin metabolic process; doxorubicin metabolic process; and protein tetramerization. Predicted to be located in mitochondrial matrix. Predicted to be part of oxidoreductase complex. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 179.2), Heart (RPKM 178.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbr4 in Genome Data Viewer
    Location:
    16p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33625734..33695067, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28629928..28684230, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31944328..31972553, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097508 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482542 Neighboring gene SH3 domain containing ring finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase. Endo S, et al. Biochem Biophys Res Commun, 2008 Dec 26. PMID 19000905
    2. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Venkatesan R, et al. Nat Commun, 2014 Sep 9. PMID 25203508
    3. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. Bains OS, et al. J Pharmacol Exp Ther, 2010 Dec. PMID 20837989
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105271

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quinone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of oxidoreductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxidoreductase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] reductase
    Names
    3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
    KAR beta subunit
    carbonic reductase 4
    carbonyl reductase family member 4
    quinone reductase CBR4
    NP_872613.1
    XP_038950534.1
    XP_038950535.1
    XP_038950537.1
    XP_063131549.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182672.2 → NP_872613.1  3-oxoacyl-[acyl-carrier-protein] reductase

      See identical proteins and their annotated locations for NP_872613.1

      Status: PROVISIONAL

      Source sequence(s)
      AY305858
      UniProtKB/Swiss-Prot
      Q7TS56
      UniProtKB/TrEMBL
      A0A8I6A1W1, A6KIR4
      Conserved Domains (1) summary
      cl21454
      Location:3 → 232
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      33625734..33695067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275479.1 → XP_063131549.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X1

    2. XM_039094606.2 → XP_038950534.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

      UniProtKB/TrEMBL
      A6KIR6
      Conserved Domains (1) summary
      cl21454
      Location:2 → 163
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_039094609.2 → XP_038950537.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

      UniProtKB/TrEMBL
      A6KIR6
      Conserved Domains (1) summary
      cl21454
      Location:2 → 163
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_039094607.2 → XP_038950535.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

      UniProtKB/TrEMBL
      A6KIR6
      Conserved Domains (1) summary
      cl21454
      Location:2 → 163
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TS56.1 GenPept UniProtKB/Swiss-Prot:Q7TS56

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