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    Cemip cell migration inducing hyaluronidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308797, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cemipprovided by RGD
    Official Full Name
    cell migration inducing hyaluronidase 1provided by RGD
    Primary source
    RGD:1305254
    See related
    EnsemblRapid:ENSRNOG00000012442 AllianceGenome:RGD:1305254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305254
    Summary
    Predicted to enable several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of protein targeting to membrane. Predicted to be located in several cellular components, including clathrin-coated vesicle; endoplasmic reticulum; and nucleus. Orthologous to human CEMIP (cell migration inducing hyaluronidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 68.1), Brain (RPKM 47.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cemip in Genome Data Viewer
    Location:
    1q31
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (147316052..147471552, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (137906921..138062430, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (146069774..146226320, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485147 Neighboring gene mesoderm development LRP chaperone Neighboring gene abhydrolase domain containing 17C, depalmitoylase Neighboring gene aryl hydrocarbon receptor nuclear translocator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of the KIAA1199 gene is associated with cellular mortality. Michishita E, et al. Cancer Lett, 2006 Jul 28. PMID 16157444
    2. Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss. Abe S, et al. J Hum Genet, 2003. PMID 14577002
    3. Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization. Yoshida H, et al. FEBS Open Bio, 2013. PMID 24251095, Free PMC Article
    4. Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration. Evensen NA, et al. J Natl Cancer Inst, 2013 Sep 18. PMID 23990668, Free PMC Article
    5. KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. Yoshida H, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23509262, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIAA1199 protein homolog was localized in various supporting cells, including inner phalangeal, border, inner and outer pillar, and Deiters' cells.
      Title: The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ER retention sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ER retention sequence binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin heavy chain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hyaluronic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hyalurononglucosaminidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hyaluronan metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in clathrin-coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cell migration-inducing and hyaluronan-binding protein
    Names
    cell migration inducing protein, hyaluronan binding
    cell migration-inducing hyaluronan binding protein
    NP_001414784.1
    XP_063118797.1
    XP_063118798.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427855.1 → NP_001414784.1  cell migration-inducing and hyaluronan-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000037364.7, ENSRNOT00000036343.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      147316052..147471552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262728.1 → XP_063118798.1  cell migration-inducing and hyaluronan-binding protein isoform X1

      Related
      ENSRNOP00000099632.1, ENSRNOT00000135771.1

    2. XM_063262727.1 → XP_063118797.1  cell migration-inducing and hyaluronan-binding protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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