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    E4f1 E4F transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E4f1provided by RGD
    Official Full Name
    E4F transcription factor 1provided by RGD
    Primary source
    RGD:1596731
    See related
    EnsemblRapid:ENSRNOG00000009224 AllianceGenome:RGD:1596731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnase1l2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and cAMP response element binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and regulation of cell cycle process. Predicted to act upstream of or within DNA replication; positive regulation of transcription by RNA polymerase II; and regulation of mitotic cell cycle, embryonic. Predicted to be located in nuclear body and spindle. Orthologous to human E4F1 (E4F transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 33.7), Thymus (RPKM 33.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See E4f1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13978975..13999646, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13471478..13495018, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13812335..13835847, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene enoyl-CoA delta isomerase 1 Neighboring gene deoxyribonuclease 1 like 2 Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. E4F and ATF, two transcription factors that recognize the same site, can be distinguished both physically and functionally: a role for E4F in E1A trans activation. Rooney RJ, et al. Mol Cell Biol, 1990 Oct. PMID 2169022, Free PMC Article
    2. The LIM-only protein FHL2 is a negative regulator of E4F1. Paul C, et al. Oncogene, 2006 Sep 7. PMID 16652157
    3. The E4F protein is required for mitotic progression during embryonic cell cycles. Le Cam L, et al. Mol Cell Biol, 2004 Jul. PMID 15226446, Free PMC Article
    4. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Tessari MA, et al. Mol Cell Biol, 2003 Dec. PMID 14645522, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor E4F1
    Names
    deoxyribonuclease 1-like 2
    NP_001171975.1
    XP_006246087.1
    XP_038942751.1
    XP_038942752.1
    XP_038942754.1
    XP_063125902.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185046.1 → NP_001171975.1  transcription factor E4F1

      See identical proteins and their annotated locations for NP_001171975.1

      Status: VALIDATED

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HCS6, F1MAM9
      Related
      ENSRNOP00000012506.4, ENSRNOT00000012506.7
      Conserved Domains (4) summary
      COG5048
      Location:193 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:560 → 584
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13978975..13999646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086823.2 → XP_038942751.1  transcription factor E4F1 isoform X3

      Conserved Domains (5) summary
      COG5189
      Location:476 → 538
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:489 → 509
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:529 → 553
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:404 → 490
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_006246025.5 → XP_006246087.1  transcription factor E4F1 isoform X1

      See identical proteins and their annotated locations for XP_006246087.1

      UniProtKB/TrEMBL
      A6HCS6, F1MAM9
      Conserved Domains (4) summary
      COG5048
      Location:193 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:560 → 584
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063269832.1 → XP_063125902.1  transcription factor E4F1 isoform X2

    4. XM_039086826.2 → XP_038942754.1  transcription factor E4F1 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:62 → 463
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_039086824.2 → XP_038942752.1  transcription factor E4F1 isoform X4

      Related
      ENSRNOP00000107209.1, ENSRNOT00000125000.1
      Conserved Domains (2) summary
      COG5048
      Location:156 → 557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:483 → 503
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_010055243.1 RNA Sequence

    2. XR_010055242.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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