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    Arid2 AT-rich interaction domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arid2provided by RGD
    Official Full Name
    AT-rich interaction domain 2provided by RGD
    Primary source
    RGD:1311105
    See related
    EnsemblRapid:ENSRNOG00000004831 AllianceGenome:RGD:1311105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; nucleosome disassembly; and positive regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 267.6), Lung (RPKM 131.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arid2 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (129326371..129443813)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (127447192..127565987)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (137680564..137798329)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093717 Neighboring gene eukaryotic translation initiation factor 3, subunit I, pseudogene 2 Neighboring gene eukaryotic translation initiation factor 3 subunit I-like Neighboring gene SR-related CTD-associated factor 11 Neighboring gene uncharacterized LOC120093718

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma. Gao Q, et al. Cancer Sci, 2017 Jul. PMID 28498550, Free PMC Article
    2. Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer. Bala P, et al. Oncogene, 2021 Jan. PMID 33262464
    3. Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis. Jiang H, et al. Proc Natl Acad Sci U S A, 2020 Mar 3. PMID 32071245, Free PMC Article
    4. Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression. Duan Y, et al. Oncotarget, 2016 Jul 19. PMID 27351279, Free PMC Article
    5. MiR-155-5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2. Wu M, et al. Biomed Pharmacother, 2020 Feb. PMID 31918270

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circulatory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostatic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SWI/SNF superfamily-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein 2
    Names
    AT rich interactive domain 2 (Arid-rfx like)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432507.1 → NP_001419436.1  AT-rich interactive domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KC19, D3ZJU0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      129326371..129443813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_345867.10 → XP_345868.4  AT-rich interactive domain-containing protein 2 isoform X1

      Related
      ENSRNOP00000006970.6, ENSRNOT00000006970.10
      Conserved Domains (3) summary
      pfam01388
      Location:19 → 101
      ARID; ARID/BRIGHT DNA binding domain
      pfam02257
      Location:521 → 601
      RFX_DNA_binding; RFX DNA-binding domain
      pfam07223
      Location:677 → 893
      DUF1421; Protein of unknown function (DUF1421)

    2. XM_063264356.1 → XP_063120426.1  AT-rich interactive domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6KC19
      Related
      ENSRNOP00000112346.1, ENSRNOT00000139404.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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