FOXN3 forkhead box N3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOXN3provided by HGNC
Official Full Name: forkhead box N3provided by HGNC
Primary source: HGNC:HGNC:1928
See related: Ensembl:ENSG00000053254 MIM:602628; AllianceGenome:HGNC:1928
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CHES1; PRO1635; C14orf116
Summary: This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 25.7), ovary (RPKM 24.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q31.3-q32.11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (89156177..89619165, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (83379834..83842985, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (89622521..90085509, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10.
Title: CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10.
FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
Title: FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma.
Title: FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma.
miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/beta-Catenin Pathway.
Title: miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway.
FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/beta-catenin pathway.
Title: FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway.
MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway.
Title: MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway.
The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia.
Title: The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia.
FOXN3 was notably downregulated in osteosarcoma (OS) tissues and the expression of FOXN3 was negatively correlated with tumor size, metastasis and TNM stage. Also, FOXN3 suppressed the proliferation, migration and invasion of osteosarcoma cells. Furthermore, FOXN3 was demonstrated to transcriptionally suppress SIRT6 expression, thereby inhibiting MMP9 secretion.
Title: FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
liver FOXN3 and glucagon control fasting glucose.
Title: A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
these results identified a negative cross-regulatory loop between ERalpha and CHES1 that was required for growth of breast cancer cells, it might uncover novel insight into molecular mechanism of CHES1 involved in breast cancer and provide new avenues for molecular-targeted therapy in hormone-regulated breast cancer.
Title: Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
Weight loss after gastric bypass is associated with a variant at 15q26.1. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AFMB322ZD9 (e-PCR)
- UniSTS:38912

G35371 (e-PCR)
- UniSTS:80644

D14S663E (e-PCR)
- UniSTS:151561

NoName (e-PCR)
- UniSTS:491273

D17S1981 (e-PCR)
- UniSTS:41485

RH119543 (e-PCR)
- UniSTS:132626

G35943 (e-PCR)
- UniSTS:81683

SHGC-149301 (e-PCR)
- UniSTS:176916

GDB:451535 (e-PCR)
- UniSTS:99094

SHGC-154522 (e-PCR)
- UniSTS:182809

RH78193 (e-PCR)
- UniSTS:66330

SHGC-33595 (e-PCR)
- UniSTS:171034

SHGC-153839 (e-PCR)
- UniSTS:177948

D14S796 (e-PCR)
- UniSTS:153635

RH44912 (e-PCR)
- UniSTS:45360

SHGC-31015 (e-PCR)
- UniSTS:30513

D14S1309 (e-PCR)
- UniSTS:58682

G36076 (e-PCR)
- UniSTS:3659

D14S1066 (e-PCR)
- UniSTS:31053

SHGC-150901 (e-PCR)
- UniSTS:173389

G35884 (e-PCR)
- UniSTS:55123

G33025 (e-PCR)
- UniSTS:117602

RH79968 (e-PCR)
- UniSTS:87399

SHGC-84090 (e-PCR)
- UniSTS:104554

RH123154 (e-PCR)
- UniSTS:135535

STS-R16989 (e-PCR)
- UniSTS:4975

RH70765 (e-PCR)
- UniSTS:72048

SGC30907 (e-PCR)
- UniSTS:68472

SHGC-24269 (e-PCR)
- UniSTS:89990

RH80006 (e-PCR)
- UniSTS:83598

CHES1_8253 (e-PCR)
- UniSTS:467603

RH68758 (e-PCR)
- UniSTS:4770

D14S84E (e-PCR)
- UniSTS:17314

D14S825E (e-PCR)
- UniSTS:147363

D14S839 (e-PCR)
- UniSTS:62127

D14S1044 (e-PCR), detects polymorphism
- UniSTS:5042

G35779 (e-PCR)
- UniSTS:54971

G20858 (e-PCR)
- UniSTS:42940

A006I41 (e-PCR)
- UniSTS:42941

G63636 (e-PCR)
- UniSTS:140747

BCD2267 (e-PCR)
- UniSTS:35024

RH99189 (e-PCR)
- UniSTS:85971

G36276 (e-PCR)
- UniSTS:51925

SHGC-57697 (e-PCR)
- UniSTS:13527

A009Z34 (e-PCR)
- UniSTS:8170

G36293 (e-PCR)
- UniSTS:46578

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: forkhead box protein N3

Names: checkpoint suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085471.2 → NP_001078940.1 forkhead box protein N3 isoform 1

See identical proteins and their annotated locations for NP_001078940.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI084011, AL137230, AL138478, BP213901, U68723

Consensus CDS

CCDS41977.1

UniProtKB/Swiss-Prot

O00409, Q96II7, Q9UIE7

Related

ENSP00000343288.4, ENST00000345097.8

Conserved Domains (1) summary

pfam00250
Location:114 → 201

Forkhead; Forkhead domain
NM_005197.4 → NP_005188.2 forkhead box protein N3 isoform 2

See identical proteins and their annotated locations for NP_005188.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 5' UTR, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AI084011, AL138478, AL356805, BC007506, CB989352

Consensus CDS

CCDS32138.1

UniProtKB/Swiss-Prot

O00409

Related

ENSP00000452005.1, ENST00000557258.6

Conserved Domains (1) summary

pfam00250
Location:114 → 200

Forkhead; Forkhead domain