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    UST uronyl 2-sulfotransferase [ Homo sapiens (human) ]

    Gene ID: 10090, updated on 27-Dec-2024

    Summary

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    Official Symbol
    USTprovided by HGNC
    Official Full Name
    uronyl 2-sulfotransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:17223
    See related
    Ensembl:ENSG00000111962 MIM:610752; AllianceGenome:HGNC:17223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2OST
    Summary
    Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in thyroid (RPKM 10.7), adrenal (RPKM 4.5) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UST in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (148747030..149076990)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (149946826..150276839)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149068166..149398126)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25234 Neighboring gene ribosomal protein SA pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25235 Neighboring gene uncharacterized LOC124901425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149069303-149069804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149069805-149070304 Neighboring gene uncharacterized LOC107986659 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149081854-149082604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25238 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:149090389-149091019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25239 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:149139935-149140821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149184983-149185492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17654 Neighboring gene Sharpr-MPRA regulatory region 942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:149194421-149195620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149245080-149245698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149284708-149285284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149285285-149285861 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:149290736-149291326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:149291327-149291917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149293308-149294306 Neighboring gene NANOG hESC enhancer GRCh37_chr6:149301302-149301803 Neighboring gene uncharacterized LOC124901424 Neighboring gene UST antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149335755-149336309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149358711-149359296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25242 Neighboring gene UST antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25244 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149394281-149395480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25246 Neighboring gene Sharpr-MPRA regulatory region 12512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17656 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene uncharacterized LOC124901426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25247

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. Kobayashi M, et al. J Biol Chem, 1999 Apr 9. PMID 10187838
    2. Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase. Ohtake S, et al. J Biol Chem, 2005 Nov 25. PMID 16192264
    3. Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. Sulkava S, et al. Hum Mol Genet, 2013 Aug 15. PMID 23620144, Free PMC Article
    4. Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis. Fang J, et al. Sci Rep, 2016 Aug 11. PMID 27511124, Free PMC Article
    5. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. Xu D, et al. J Biol Chem, 2007 Mar 16. PMID 17227754

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that overexpression of 2OST alone in the HEK293 cells did not appreciably affect heparan sulfate (HS) chain length. Also, its simultaneous overexpression with Hsepi abolished the effect of Hsepi overexpression on the HS chain lengh.
      Title: Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.
    2. Statistical analysis showed the strongest evidence for a variant located in an intron of UST associated with job-related exhaustion.
      Title: Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    6. 2OST transfers sulfate preferentially to the GlcA residue located in a unique sequence, -GalNAc(4SO(4))-GlcA-GalNAc(6SO(4))-.
      Title: Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase.
    7. analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes
      Title: Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.
    EBI GWAS Catalog
    Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
    EBI GWAS Catalog
    Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chondroitin 2-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in dermatan sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dermatan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uronyl 2-sulfotransferase
    Names
    dermatan/chondroitin sulfate 2-sulfotransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005715.3 → NP_005706.1  uronyl 2-sulfotransferase

      See identical proteins and their annotated locations for NP_005706.1

      Status: VALIDATED

      Source sequence(s)
      AB020316, AI570697, AL807246, BC093668, CA842761, DB496757
      Consensus CDS
      CCDS5213.1
      UniProtKB/Swiss-Prot
      B2RCX6, Q9Y2C2
      UniProtKB/TrEMBL
      A8KA57
      Related
      ENSP00000356433.4, ENST00000367463.5
      Conserved Domains (1) summary
      cl22970
      Location:104 → 356
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      148747030..149076990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418047.1 → XP_047274003.1  uronyl 2-sulfotransferase isoform X1

    2. XM_047418048.1 → XP_047274004.1  uronyl 2-sulfotransferase isoform X1

    3. XM_011535378.4 → XP_011533680.1  uronyl 2-sulfotransferase isoform X2

      Conserved Domains (1) summary
      cl22970
      Location:104 → 211
      Sulfotransfer_2; Sulfotransferase family

    4. XM_017010152.2 → XP_016865641.1  uronyl 2-sulfotransferase isoform X3

    RNA

    1. XR_001743088.3 RNA Sequence

    2. XR_007059195.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      149946826..150276839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353990.1 → XP_054209965.1  uronyl 2-sulfotransferase isoform X1

    2. XM_054353991.1 → XP_054209966.1  uronyl 2-sulfotransferase isoform X2

    3. XM_054353992.1 → XP_054209967.1  uronyl 2-sulfotransferase isoform X3

    RNA

    1. XR_008487234.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2C2.1 GenPept UniProtKB/Swiss-Prot:Q9Y2C2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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