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    GPR183 G protein-coupled receptor 183 [ Homo sapiens (human) ]

    Gene ID: 1880, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR183provided by HGNC
    Official Full Name
    G protein-coupled receptor 183provided by HGNC
    Primary source
    HGNC:HGNC:3128
    See related
    Ensembl:ENSG00000169508 MIM:605741; AllianceGenome:HGNC:3128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EBI2; hEBI2
    Summary
    This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 44.7), bone marrow (RPKM 34.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR183 in Genome Data Viewer
    Location:
    13q32.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (99294539..99307399, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98504775..98517640, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99946793..99959653, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene uncharacterized LOC124903198 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:99914553-99914775 Neighboring gene G protein-coupled receptor 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99955752-99956300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:99956301-99956847 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:99966417-99967616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99994828-99995328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:99995329-99995829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7934 Neighboring gene FKSG29 Neighboring gene microRNA 623

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 183 (GPR183) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxysterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxysterol binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T follicular helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dendritic cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mature B cell differentiation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of astrocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 183
    Names
    EBV-induced G-protein coupled receptor 2
    Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
    epstein-Barr virus-induced G-protein coupled receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004951.5NP_004942.1  G-protein coupled receptor 183

      See identical proteins and their annotated locations for NP_004942.1

      Status: REVIEWED

      Source sequence(s)
      AK313443, AW574697, BC020752
      Consensus CDS
      CCDS9492.1
      UniProtKB/Swiss-Prot
      B2R8N5, P32249, Q53F99, Q5JUH7
      Related
      ENSP00000365596.4, ENST00000376414.5
      Conserved Domains (1) summary
      cd15159
      Location:32319
      7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      99294539..99307399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      98504775..98517640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)