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    NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

    Gene ID: 4887, updated on 10-Dec-2024

    Summary

    Official Symbol
    NPY2Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y2provided by HGNC
    Primary source
    HGNC:HGNC:7957
    See related
    Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPY2-R
    Summary
    Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See NPY2R in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155173723..155217076)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158505608..158548978)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094875..156138228)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene RNA binding motif protein 46 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:155837105-155837739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875070-155875570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875571-155876071 Neighboring gene uncharacterized LOC105377501 Neighboring gene NANOG hESC enhancer GRCh37_chr4:156034857-156035436 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene microtubule associated protein 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cilium PubMed 
    located_in non-motile cilium  
    located_in plasma membrane  

    General protein information

    Preferred Names
    neuropeptide Y receptor type 2
    Names
    NPY-Y2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000910.4 → NP_000901.1  neuropeptide Y receptor type 2

      See identical proteins and their annotated locations for NP_000901.1

      Status: VALIDATED

      Source sequence(s)
      U36269, U42766
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Related
      ENSP00000332591.3, ENST00000329476.4
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001370180.1 → NP_001357109.1  neuropeptide Y receptor type 2

      Status: VALIDATED

      Source sequence(s)
      AC104407
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Related
      ENSP00000426366.1, ENST00000506608.1
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001375470.1 → NP_001362399.1  neuropeptide Y receptor type 2

      Status: VALIDATED

      Source sequence(s)
      AC104407
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      155173723..155217076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      158505608..158548978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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