SCRIB scribble planar cell polarity protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCRIBprovided by HGNC
Official Full Name: scribble planar cell polarity proteinprovided by HGNC
Primary source: HGNC:HGNC:30377
See related: Ensembl:ENSG00000180900 MIM:607733; AllianceGenome:HGNC:30377
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB
Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in colon (RPKM 9.3), skin (RPKM 9.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (143790925..143815773, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (144947418..144972471, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (144873095..144897943, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The water channels aquaporin-1 and aquaporin-3 interact with and affect the cell polarity protein Scribble in 3D in vitro models of breast cancer.
Title: The water channels aquaporin-1 and aquaporin-3 interact with and affect the cell polarity protein Scribble in 3D in vitro models of breast cancer.
Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status.
Title: Moderate SCRIB Expression Levels Correlate with Worse Prognosis in OPSCC Patients Regardless of HPV Status.
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Title: An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.
Title: Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.
The cell polarity protein Scribble is downregulated by the water channel aquaporin-5 in breast cancer cells.
Title: The cell polarity protein Scribble is downregulated by the water channel aquaporin-5 in breast cancer cells.
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms.
Title: Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms.
PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.
Title: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.
MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.
Title: MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal Cells.
Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer.
Title: Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer.
Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression.
Title: Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70666 (e-PCR)
- UniSTS:37443

WI-19511 (e-PCR)
- UniSTS:31309

RH25368 (e-PCR)
- UniSTS:5249

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte cell migration	IEA Inferred from Electronic Annotation more info
involved_in auditory receptor cell stereocilium organization	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cochlear nucleus development	IEA Inferred from Electronic Annotation more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of T cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in mammary gland duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in polarized epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in protein localization to adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle targeting	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Scrib-APC-beta-catenin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	NAS Non-traceable Author Statement more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IDA Inferred from Direct Assay more info
colocalizes_with cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extrinsic component of postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein scribble homolog

Names: scribbled homolog; scribbled planar cell polarity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030583.2 RefSeqGene

Range

5000..29848

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_015356.5 → NP_056171.3 protein scribble homolog isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC105219, KF458881

Consensus CDS

CCDS6411.1

UniProtKB/TrEMBL

A0A0G2JNZ2, A0A669KB89

Related

ENSP00000322938.3, ENST00000320476.7

Conserved Domains (5) summary

smart00228
Location:725 → 813

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 401

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1002 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
NM_182706.5 → NP_874365.3 protein scribble homolog isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC105219, KF458881

Consensus CDS

CCDS6412.1

UniProtKB/Swiss-Prot

Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1

UniProtKB/TrEMBL

A0A0G2JPP5, A0A669KB89

Related

ENSP00000349486.2, ENST00000356994.7

Conserved Domains (6) summary

smart00228
Location:725 → 813

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 401

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1002 → 1090

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1555 → 1593

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM