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    ZNF322 zinc finger protein 322 [ Homo sapiens (human) ]

    Gene ID: 79692, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF322provided by HGNC
    Official Full Name
    zinc finger protein 322provided by HGNC
    Primary source
    HGNC:HGNC:23640
    See related
    Ensembl:ENSG00000181315 MIM:610847; AllianceGenome:HGNC:23640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCG12; ZNF388; ZNF489; ZNF322A
    Summary
    ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 9.4), thyroid (RPKM 9.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF322 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26634383..26659746, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26502803..26528154, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26634611..26659974, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374989 Neighboring gene vomeronasal 1 receptor 14 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659404-26659904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659905-26660405 Neighboring gene uncharacterized LOC102724851 Neighboring gene tRNA-Ala (anticodon AGC) 14-1 Neighboring gene tRNA-Ala (anticodon AGC) 12-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. Li Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555580
    2. AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression. Liao SY, et al. Oncogene, 2019 Oct. PMID 31399647
    3. Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer. Huang SH, et al. Biofactors, 2024 Jan-Feb. PMID 37647209
    4. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. Cheung CHY, et al. J Biomed Sci, 2020 Jun 23. PMID 32576196, Free PMC Article
    5. Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression. Jen J, et al. Cell Death Differ, 2019 Jul. PMID 30258097, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer.
      Title: Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer.
    2. Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.
      Title: Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.
    3. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer.
      Title: ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer.
    4. The ZNF322A-centered transcriptome promotes lung tumorigenesis and ZNF322A acts as a transcription suppressor of c-Myc to maintain lung cancer stem cell-like properties by shifting metabolism towards oxidative phosphorylation.
      Title: Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression.
    5. results reveal a new mechanism of AKT signaling in promoting ZNF322A protein stability and transcriptional activity in lung cancer cell, xenograft, and clinical models
      Title: AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression.
    6. Silencing ZNF322 recapitulated the cellular and molecular effects seen upon miR-4317 overexpression.
      Title: miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322.
    7. Our results reveal a new mechanism of ZNF322A oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A overexpression and promotes cancer progression
      Title: CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression.
    8. ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
      Title: Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. These results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways.
      Title: ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23393

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 322
    Names
    HLA complex group 12
    zinc finger protein 322A
    zinc finger protein 388
    zinc finger protein 489

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242797.2 → NP_001229726.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DA481584
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000482607.1, ENST00000622479.4
      Conserved Domains (3) summary
      COG5048
      Location:69 → 219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001242798.2 → NP_001229727.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DA437716
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000483223.1, ENST00000607204.5
      Conserved Domains (3) summary
      COG5048
      Location:69 → 219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001242799.2 → NP_001229728.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DB454351
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000478899.1, ENST00000456172.5
      Conserved Domains (3) summary
      COG5048
      Location:69 → 219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_024639.5 → NP_078915.2  zinc finger protein 322

      See identical proteins and their annotated locations for NP_078915.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK290038, AL513548, BX474628
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000418897.1, ENST00000415922.7
      Conserved Domains (3) summary
      COG5048
      Location:69 → 219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207 → 291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26634383..26659746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791780.1 Reference GRCh38.p14 PATCHES

      Range
      180572..205907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008485816.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26502803..26528154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487434.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6U7Q0.2 GenPept UniProtKB/Swiss-Prot:Q6U7Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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