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    PROSER2 proline and serine rich 2 [ Homo sapiens (human) ]

    Gene ID: 254427, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PROSER2provided by HGNC
    Official Full Name
    proline and serine rich 2provided by HGNC
    Primary source
    HGNC:HGNC:23728
    See related
    Ensembl:ENSG00000148426 AllianceGenome:HGNC:23728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf47
    Expression
    Broad expression in liver (RPKM 3.3), placenta (RPKM 2.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PROSER2 in Genome Data Viewer
    Location:
    10p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (11823356..11872277)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (11834808..11883725)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (11865355..11914276)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379850 Neighboring gene uncharacterized LOC105376415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:11835512-11836711 Neighboring gene PROSER2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:11917739-11918586 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:11923543-11924742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3027 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:11940130-11941329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3028 Neighboring gene RNA, U6 small nuclear 1095, pseudogene Neighboring gene UPF2 regulator of nonsense mediated mRNA decay Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3031 Neighboring gene uncharacterized LOC105376416

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma. Lee YS, et al. J Proteome Res, 2024 Mar 1. PMID 38293943,
    2. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Wang C, et al. Nat Commun, 2020 Jun 22. PMID 32572027, Free PMC Article
    3. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article
    4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
    5. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma.
      Title: New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC35403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline and serine-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153256.4 → NP_694988.3  proline and serine-rich protein 2

      See identical proteins and their annotated locations for NP_694988.3

      Status: VALIDATED

      Source sequence(s)
      AL138898, BC048800
      Consensus CDS
      CCDS7085.1
      UniProtKB/Swiss-Prot
      D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317
      Related
      ENSP00000277570.5, ENST00000277570.10
      Conserved Domains (2) summary
      PHA03247
      Location:92 → 405
      PHA03247; large tegument protein UL36; Provisional
      pfam15385
      Location:396 → 433
      SARG; Specifically androgen-regulated gene protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      11823356..11872277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519438.3 → XP_011517740.1  proline and serine-rich protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011517740.1

      UniProtKB/Swiss-Prot
      D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317
      Conserved Domains (2) summary
      PHA03247
      Location:92 → 405
      PHA03247; large tegument protein UL36; Provisional
      pfam15385
      Location:396 → 433
      SARG; Specifically androgen-regulated gene protein

    2. XM_047424963.1 → XP_047280919.1  proline and serine-rich protein 2 isoform X2

      UniProtKB/TrEMBL
      D3DRR9
      Related
      ENSP00000368498.1, ENST00000379200.1

    3. XM_047424964.1 → XP_047280920.1  proline and serine-rich protein 2 isoform X2

      UniProtKB/TrEMBL
      D3DRR9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      11834808..11883725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365416.1 → XP_054221391.1  proline and serine-rich protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317

    2. XM_054365417.1 → XP_054221392.1  proline and serine-rich protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317

    3. XM_054365418.1 → XP_054221393.1  proline and serine-rich protein 2 isoform X2

      UniProtKB/TrEMBL
      D3DRR9

    4. XM_054365419.1 → XP_054221394.1  proline and serine-rich protein 2 isoform X2

      UniProtKB/TrEMBL
      D3DRR9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WR7.2 GenPept UniProtKB/Swiss-Prot:Q86WR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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