WDR89 WD repeat domain 89 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WDR89provided by HGNC
Official Full Name: WD repeat domain 89provided by HGNC
Primary source: HGNC:HGNC:20489
See related: Ensembl:ENSG00000140006 AllianceGenome:HGNC:20489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MSTP050; C14orf150
Summary: Predicted to act upstream of or within corpus callosum development and ventricular system development. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lymph node (RPKM 4.5), thyroid (RPKM 4.4) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14q23.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (63597039..63641871, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (57804429..57849265, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (64063757..64108589, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-36643 (e-PCR)
- UniSTS:17971

SHGC-30609 (e-PCR)
- UniSTS:43629

D14S1001 (e-PCR)
- UniSTS:50608

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in ventricular system development	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: WD repeat-containing protein 89

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008726.3 → NP_001008726.1 WD repeat-containing protein 89

See identical proteins and their annotated locations for NP_001008726.1

Status: VALIDATED

Source sequence(s)

BC010698, BP278550, DA882425

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001258272.2 → NP_001245201.1 WD repeat-containing protein 89

See identical proteins and their annotated locations for NP_001245201.1

Status: VALIDATED

Source sequence(s)

BC010698, BP278550, DA882425, DB178690

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Related

ENSP00000267522.3, ENST00000267522.7

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382423.1 → NP_001369352.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382424.1 → NP_001369353.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382425.1 → NP_001369354.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382426.1 → NP_001369355.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382427.1 → NP_001369356.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382428.1 → NP_001369357.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001382429.1 → NP_001369358.1 WD repeat-containing protein 89

Status: VALIDATED

Source sequence(s)

AL136038

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_080666.4 → NP_542397.1 WD repeat-containing protein 89

See identical proteins and their annotated locations for NP_542397.1

Status: VALIDATED

Source sequence(s)

BC010698, DA882425

Consensus CDS

CCDS9759.1

UniProtKB/Swiss-Prot

Q96FK6

Related

ENSP00000480112.1, ENST00000620954.2

Conserved Domains (2) summary

sd00039
Location:74 → 112

7WD40; WD40 repeat [structural motif]

cl29593
Location:41 → 349

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

63597039..63641871 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536383.3 → XP_011534685.1 WD repeat-containing protein 89 isoform X1

Conserved Domains (3) summary

COG2319
Location:69 → 387

WD40; WD40 repeat [General function prediction only]

sd00039
Location:112 → 150

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 387

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...