PGGT1B protein geranylgeranyltransferase type I subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGGT1Bprovided by HGNC
Official Full Name: protein geranylgeranyltransferase type I subunit betaprovided by HGNC
Primary source: HGNC:HGNC:8895
See related: Ensembl:ENSG00000164219 MIM:602031; AllianceGenome:HGNC:8895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BGGI; GGTI
Summary: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Expression: Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q22.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (115204012..115262877, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (115713562..115776201, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (114539709..114598574, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The diagnostic significance of PGGT1B in psoriasis.
Title: The diagnostic significance of PGGT1B in psoriasis.
our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
Title: Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion.
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
Title: Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.
Title: Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.
results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion
Title: Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
Title: Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	FITC-labeled Tat 47-59 peptide downregulates gene expression of protein geranylgeranyltransferase type I, beta subunit (PGGT1B) in U-937 macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68128 (e-PCR)
- UniSTS:86026

RH122222 (e-PCR)
- UniSTS:138121

RH40185 (e-PCR)
- UniSTS:90252

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CAAX-protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of CAAX-protein geranylgeranyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: geranylgeranyl transferase type-1 subunit beta

Names: CTC-428G20.3; GGTase-I-beta; geranylgeranyl transferase type I subunit beta; geranylgeranyltransferase type I beta subunit; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta

NP_005014.2

EC 2.5.1.59

XP_005272077.2

EC 2.5.1.59

XP_011541792.1

EC 2.5.1.59

XP_047273270.1

EC 2.5.1.59

XP_054208798.1

EC 2.5.1.59

XP_054208799.1

EC 2.5.1.59

XP_054208800.1

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005023.4 → NP_005014.2 geranylgeranyl transferase type-1 subunit beta

See identical proteins and their annotated locations for NP_005014.2

Status: VALIDATED

Source sequence(s)

AC008494, AL520655, AW382606, DA024020

Consensus CDS

CCDS4116.1

UniProtKB/Swiss-Prot

P53609, Q5MJP9

Related

ENSP00000404676.1, ENST00000419445.6

Conserved Domains (1) summary

cd02895
Location:22 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

115204012..115262877 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011543490.3 → XP_011541792.1 geranylgeranyl transferase type-1 subunit beta isoform X1

Conserved Domains (1) summary

cd02895
Location:22 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
XM_005272020.4 → XP_005272077.2 geranylgeranyl transferase type-1 subunit beta isoform X2

See identical proteins and their annotated locations for XP_005272077.2

Conserved Domains (1) summary

cd02895
Location:22 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
XM_047417314.1 → XP_047273270.1 geranylgeranyl transferase type-1 subunit beta isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

115713562..115776201 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352823.1 → XP_054208798.1 geranylgeranyl transferase type-1 subunit beta isoform X1
XM_054352824.1 → XP_054208799.1 geranylgeranyl transferase type-1 subunit beta isoform X2
XM_054352825.1 → XP_054208800.1 geranylgeranyl transferase type-1 subunit beta isoform X3