U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ANKRD45 ankyrin repeat domain 45 [ Homo sapiens (human) ]

    Gene ID: 339416, updated on 10-Dec-2024

    Summary

    Official Symbol
    ANKRD45provided by HGNC
    Official Full Name
    ankyrin repeat domain 45provided by HGNC
    Primary source
    HGNC:HGNC:24786
    See related
    Ensembl:ENSG00000183831 MIM:618712; AllianceGenome:HGNC:24786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT117
    Summary
    Involved in cell population proliferation. Located in cleavage furrow; cytoplasm; and midbody. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 3.3), brain (RPKM 0.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ANKRD45 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173608336..173715185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (172966487..173073343, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173577475..173638990, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904456 Neighboring gene MPRA-validated peak459 silencer Neighboring gene Sharpr-MPRA regulatory region 4744 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173473949-173475148 Neighboring gene peroxiredoxin 6 Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene uncharacterized LOC105371619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173610829-173612028 Neighboring gene small nucleolar RNA U13 Neighboring gene testis expressed 50 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2115 Neighboring gene kelch like family member 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:173728073-173728573 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene RN7SK pseudogene 160

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ45235, MGC161631, MGC161633

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in cleavage furrow PubMed 
    located_in cytoplasm PubMed 
    located_in midbody PubMed 

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 45
    Names
    cancer/testis antigen 117

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198493.3NP_940895.1  ankyrin repeat domain-containing protein 45

      See identical proteins and their annotated locations for NP_940895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AK127170, AL139142, BC126355
      Consensus CDS
      CCDS1309.1
      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
      Related
      ENSP00000331268.2, ENST00000333279.3
      Conserved Domains (3) summary
      cd00204
      Location:74162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
      cl26953
      Location:144240
      HSP70; Hsp70 protein

    RNA

    1. NR_158771.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139142, BX248409

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173608336..173715185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001123.2XP_016856612.1  ankyrin repeat domain-containing protein 45 isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:94182
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:97150
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:97127
      ANK; ANK repeat [structural motif]
    2. XM_047419195.1XP_047275151.1  ankyrin repeat domain-containing protein 45 isoform X1

    3. XM_011509470.3XP_011507772.1  ankyrin repeat domain-containing protein 45 isoform X2

      See identical proteins and their annotated locations for XP_011507772.1

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
      Conserved Domains (3) summary
      cd00204
      Location:74162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
      cl26953
      Location:144240
      HSP70; Hsp70 protein
    4. XM_047419198.1XP_047275154.1  ankyrin repeat domain-containing protein 45 isoform X2

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
    5. XM_024446627.2XP_024302395.1  ankyrin repeat domain-containing protein 45 isoform X2

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
      Conserved Domains (3) summary
      cd00204
      Location:74162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:77107
      ANK; ANK repeat [structural motif]
      cl26953
      Location:144240
      HSP70; Hsp70 protein
    6. XM_047419206.1XP_047275162.1  ankyrin repeat domain-containing protein 45 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      172966487..173073343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336244.1XP_054192219.1  ankyrin repeat domain-containing protein 45 isoform X1

    2. XM_054336245.1XP_054192220.1  ankyrin repeat domain-containing protein 45 isoform X1

    3. XM_054336248.1XP_054192223.1  ankyrin repeat domain-containing protein 45 isoform X2

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
    4. XM_054336247.1XP_054192222.1  ankyrin repeat domain-containing protein 45 isoform X2

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
    5. XM_054336246.1XP_054192221.1  ankyrin repeat domain-containing protein 45 isoform X2

      UniProtKB/Swiss-Prot
      A1A4G2, Q5TZF3, Q6ZST1
    6. XM_054336249.1XP_054192224.1  ankyrin repeat domain-containing protein 45 isoform X3

    Loading
    Loading
    External link. Please review our privacy policy.