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    Cct6b chaperonin containing TCP1 subunit 6B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cct6bprovided by RGD
    Official Full Name
    chaperonin containing TCP1 subunit 6Bprovided by RGD
    Primary source
    RGD:1359453
    See related
    EnsemblRapid:ENSRNOG00000007523 AllianceGenome:RGD:1359453
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561014
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT6B (chaperonin containing TCP1 subunit 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 283.0) and Lung (RPKM 29.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cct6b in Genome Data Viewer
    Location:
    10q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68150111..68198932, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67652461..67701385, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70069479..70118194, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095155 Neighboring gene U4 spliceosomal RNA Neighboring gene transcription factor BTF3 homolog 4 pseudogene Neighboring gene uncharacterized LOC102547954 Neighboring gene zinc finger protein 830 Neighboring gene DNA ligase 3 Neighboring gene ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture. Yi X, et al. J Orthop Surg Res, 2019 May 9. PMID 31072365, Free PMC Article
    2. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota H, et al. FEBS Lett, 1997 Jan 27. PMID 9013858
    3. Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis. Hynes G, et al. FEBS Lett, 1995 Jan 23. PMID 7828721
    4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
    5. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCT6b overexpression significantly inhibited fibroblasts functions in a model of joint contracture.
      Title: Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit zeta-2
    Names
    chaperonin containing Tcp1, subunit 6B (zeta 2)
    chaperonin subunit 6b (zeta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014228.1 → NP_001014250.1  T-complex protein 1 subunit zeta-2

      See identical proteins and their annotated locations for NP_001014250.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079020
      UniProtKB/TrEMBL
      F1M2D2, Q6AYJ7
      Related
      ENSRNOP00000009944.6, ENSRNOT00000009944.8
      Conserved Domains (1) summary
      TIGR02347
      Location:3 → 530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68150111..68198932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269529.1 → XP_063125599.1  T-complex protein 1 subunit zeta-2 isoform X1

    2. XM_039086489.2 → XP_038942417.1  T-complex protein 1 subunit zeta-2 isoform X3

      Conserved Domains (1) summary
      TIGR02347
      Location:1 → 310
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    3. XM_063269531.1 → XP_063125601.1  T-complex protein 1 subunit zeta-2 isoform X2

    4. XM_063269527.1 → XP_063125597.1  T-complex protein 1 subunit zeta-2 isoform X1

    5. XM_063269530.1 → XP_063125600.1  T-complex protein 1 subunit zeta-2 isoform X1

    6. XM_063269528.1 → XP_063125598.1  T-complex protein 1 subunit zeta-2 isoform X1

    7. XM_063269532.1 → XP_063125602.1  T-complex protein 1 subunit zeta-2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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