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    Cenpl centromere protein L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenplprovided by RGD
    Official Full Name
    centromere protein Lprovided by RGD
    Primary source
    RGD:1311868
    See related
    EnsemblRapid:ENSRNOG00000038789 AllianceGenome:RGD:1311868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311868
    Summary
    Predicted to be located in chromosome and nucleus. Predicted to be part of inner kinetochore. Orthologous to human CENPL (centromere protein L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 110.6), Spleen (RPKM 88.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpl in Genome Data Viewer
    Location:
    13q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (75870479..75885466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73337235..73352115)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (78886092..78901025)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Small nucleolar RNA SNORD81 Neighboring gene growth arrest specific 5 Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene ribosomal protein S10-like Neighboring gene kelch-like family member 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125045

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein L
    Names
    CENP-L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033061.2 → NP_001028233.2  centromere protein L isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
      Source sequence(s)
      BC079467
      UniProtKB/TrEMBL
      A0A0A6YYD9, A0A8L2QZG7
      Related
      ENSRNOP00000109606.1, ENSRNOT00000134960.1
      Conserved Domains (1) summary
      pfam13092
      Location:185 → 331
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    2. NM_001244761.1 → NP_001231690.1  centromere protein L isoform 2

      See identical proteins and their annotated locations for NP_001231690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      BC089893
      UniProtKB/Swiss-Prot
      Q0P5Q6, Q3ZAU7
      UniProtKB/TrEMBL
      A0A8L2QZG7, A6ID73
      Related
      ENSRNOP00000056033.3, ENSRNOT00000059266.5
      Conserved Domains (1) summary
      pfam13092
      Location:178 → 324
      CENP-L; Kinetochore complex Sim4 subunit Fta1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      75870479..75885466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250099.5 → XP_006250161.1  centromere protein L isoform X1

      UniProtKB/TrEMBL
      A0A8L2QZG7
      Related
      ENSRNOP00000100501.1, ENSRNOT00000129382.1
      Conserved Domains (1) summary
      pfam13092
      Location:185 → 329
      CENP-L; Kinetochore complex Sim4 subunit Fta1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZAU7.1 GenPept UniProtKB/Swiss-Prot:Q3ZAU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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