Nsd1 nuclear receptor binding SET domain protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nsd1provided by RGD
Official Full Name: nuclear receptor binding SET domain protein 1provided by RGD
Primary source: RGD:1307748
See related: EnsemblRapid:ENSRNOG00000016680 AllianceGenome:RGD:1307748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including nuclear receptor binding activity; protein-lysine N-methyltransferase activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of DNA-templated transcription. Predicted to act upstream of or within gastrulation with mouth forming second and regulation of peptidyl-serine phosphorylation. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 292.0), Spleen (RPKM 243.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9317085..9431528, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9311963..9426373, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9840859..9955391, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH136183 (e-PCR)
- UniSTS:210178

RH137723 (e-PCR)
- UniSTS:219810

D17Rat101 (e-PCR)
- UniSTS:118438

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H3K36 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K20 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase, H3 lysine-36 specific

Names: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

NP_001388465.1

EC 2.1.1.354

XP_006253683.1

EC 2.1.1.354

XP_006253684.1

EC 2.1.1.354

XP_006253685.1

EC 2.1.1.354

XP_006253686.1

EC 2.1.1.354

XP_006253689.1

EC 2.1.1.354

XP_008769713.1

EC 2.1.1.354

XP_038951546.1

EC 2.1.1.354

XP_038951547.1

EC 2.1.1.354

XP_038951548.1

EC 2.1.1.354

XP_038951549.1

EC 2.1.1.354

XP_038951550.1

EC 2.1.1.354

XP_038951551.1

EC 2.1.1.354

XP_038951553.1

EC 2.1.1.354

XP_063132407.1

EC 2.1.1.354

XP_063132408.1

EC 2.1.1.354

XP_063132409.1

EC 2.1.1.354

XP_063132410.1

EC 2.1.1.354

XP_063132411.1

EC 2.1.1.354

XP_063132412.1

EC 2.1.1.354

XP_063132413.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401536.1 → NP_001388465.1 histone-lysine N-methyltransferase, H3 lysine-36 specific

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6AMN8

Related

ENSRNOP00000094644.1, ENSRNOT00000118233.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9317085..9431528 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095620.2 → XP_038951548.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4, A6KAU7, D4AA06

Conserved Domains (12) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1483 → 1577

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1952 → 2324

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1183 → 1316

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1274 → 1316

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1321 → 1367

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1368 → 1421

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1438 → 1477

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1849 → 1891

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1670 → 1811

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1630 → 1668

AWS; AWS domain

pfam17982
Location:1890 → 1939

C5HCH; NSD Cys-His rich domain
XM_006253624.5 → XP_006253686.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

See identical proteins and their annotated locations for XP_006253686.1

UniProtKB/TrEMBL

A0A8I6A1J6, A0A8I6AMN8, A6KAU6

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2118 → 2160

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_063276340.1 → XP_063132410.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4
XM_063276337.1 → XP_063132407.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

UniProtKB/TrEMBL

A0A8I6AMN8

Related

ENSRNOP00000084557.1, ENSRNOT00000105851.2
XM_039095619.2 → XP_038951547.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4, A6KAU7, D4AA06

Conserved Domains (12) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1483 → 1577

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1952 → 2324

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1183 → 1316

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1274 → 1316

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1321 → 1367

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1368 → 1421

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1438 → 1477

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1849 → 1891

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1670 → 1811

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1630 → 1668

AWS; AWS domain

pfam17982
Location:1890 → 1939

C5HCH; NSD Cys-His rich domain
XM_006253621.5 → XP_006253683.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

See identical proteins and their annotated locations for XP_006253683.1

UniProtKB/TrEMBL

A0A8I6A1J6, A0A8I6AMN8, A6KAU6

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2118 → 2160

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_063276341.1 → XP_063132411.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4
XM_063276339.1 → XP_063132409.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

UniProtKB/TrEMBL

A0A8I6AMN8
XM_063276343.1 → XP_063132413.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4
XM_063276338.1 → XP_063132408.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

UniProtKB/TrEMBL

A0A8I6AMN8
XM_006253623.4 → XP_006253685.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

See identical proteins and their annotated locations for XP_006253685.1

UniProtKB/TrEMBL

A0A8I6A1J6, A0A8I6AMN8, A6KAU6

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2118 → 2160

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_039095618.2 → XP_038951546.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4, A6KAU7, D4AA06

Conserved Domains (12) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1483 → 1577

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1952 → 2324

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1183 → 1316

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1274 → 1316

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1321 → 1367

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1368 → 1421

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1438 → 1477

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1849 → 1891

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1670 → 1811

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1630 → 1668

AWS; AWS domain

pfam17982
Location:1890 → 1939

C5HCH; NSD Cys-His rich domain
XM_006253622.5 → XP_006253684.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

See identical proteins and their annotated locations for XP_006253684.1

UniProtKB/TrEMBL

A0A8I6A1J6, A0A8I6AMN8, A6KAU6

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2118 → 2160

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_039095621.2 → XP_038951549.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4, A6KAU7, D4AA06

Conserved Domains (12) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1483 → 1577

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1952 → 2324

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1183 → 1316

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1274 → 1316

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1321 → 1367

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1368 → 1421

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1438 → 1477

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1849 → 1891

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1670 → 1811

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1630 → 1668

AWS; AWS domain

pfam17982
Location:1890 → 1939

C5HCH; NSD Cys-His rich domain
XM_039095622.2 → XP_038951550.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4, A6KAU7, D4AA06

Related

ENSRNOP00000077028.1, ENSRNOT00000107527.2

Conserved Domains (12) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1483 → 1577

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1952 → 2324

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1183 → 1316

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1274 → 1316

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1321 → 1367

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1368 → 1421

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1438 → 1477

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1849 → 1891

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1670 → 1811

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1630 → 1668

AWS; AWS domain

pfam17982
Location:1890 → 1939

C5HCH; NSD Cys-His rich domain
XM_008771491.4 → XP_008769713.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

See identical proteins and their annotated locations for XP_008769713.1

UniProtKB/TrEMBL

A0A8I6A1J6, A0A8I6AMN8, A6KAU6

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2118 → 2160

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_063276342.1 → XP_063132412.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

UniProtKB/TrEMBL

A0A8I5YBL4
XM_039095623.2 → XP_038951551.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

UniProtKB/TrEMBL

A6KAU7, D4AA06

Related

ENSRNOP00000057648.3, ENSRNOT00000060928.4

Conserved Domains (12) summary

cd05837
Location:14 → 124

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1447 → 1541

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

PHA03247
Location:1916 → 2288

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1147 → 1280

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1238 → 1280

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1285 → 1331

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1332 → 1385

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1402 → 1441

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1813 → 1855

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd19210
Location:1634 → 1775

SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

pfam17907
Location:1594 → 1632

AWS; AWS domain

pfam17982
Location:1854 → 1903

C5HCH; NSD Cys-His rich domain
XM_006253627.5 → XP_006253689.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X4

See identical proteins and their annotated locations for XP_006253689.1

Conserved Domains (9) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1752 → 1846

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1889 → 1939

AWS; associated with SET domains

smart00317
Location:1940 → 2063

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd15648
Location:1543 → 1585

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1590 → 1636

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1637 → 1690

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1707 → 1746

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cl22851
Location:2118 → 2152

PHD_SF; PHD finger superfamily
XM_039095625.2 → XP_038951553.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X5

Conserved Domains (1) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107337.1: Suppressed sequence

Description

NM_001107337.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.