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    Elmo3 engulfment and cell motility 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elmo3provided by RGD
    Official Full Name
    engulfment and cell motility 3provided by RGD
    Primary source
    RGD:1304734
    See related
    EnsemblRapid:ENSRNOG00000015800 AllianceGenome:RGD:1304734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in actin filament organization and cell motility. Predicted to be located in cytoplasm. Orthologous to human ELMO3 (engulfment and cell motility 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 136.6), Lung (RPKM 89.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elmo3 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50091883..50096324)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33181952..33186399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37260330..37264832)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene exocyst complex component 3-like 1 Neighboring gene E2F transcription factor 4 Neighboring gene microRNA 6318 Neighboring gene microRNA 328 Neighboring gene leucine rich repeat containing 29 Neighboring gene transmembrane protein 208

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124673

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 3
    Names
    engulfment and cell motility 3, ced-12 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030028.1 → NP_001025199.1  engulfment and cell motility protein 3

      See identical proteins and their annotated locations for NP_001025199.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099761
      UniProtKB/Swiss-Prot
      Q499U2
      UniProtKB/TrEMBL
      A0A8I5YBT5
      Related
      ENSRNOP00000076644.1, ENSRNOT00000097929.2
      Conserved Domains (3) summary
      pfam04727
      Location:293 → 463
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 267
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:534 → 663
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50091883..50096324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097605.2 → XP_038953533.1  engulfment and cell motility protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBT5
      Related
      ENSRNOP00000021362.7, ENSRNOT00000021362.8
      Conserved Domains (3) summary
      pfam04727
      Location:297 → 473
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:121 → 272
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:539 → 668
      PH-like; Pleckstrin homology-like domain

    2. XM_039097606.2 → XP_038953534.1  engulfment and cell motility protein 3 isoform X2

      Conserved Domains (3) summary
      pfam04727
      Location:297 → 473
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:121 → 272
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:539 → 564
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_005496634.2 RNA Sequence

    2. XR_005496633.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499U2.1 GenPept UniProtKB/Swiss-Prot:Q499U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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