Rhobtb3 Rho-related BTB domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhobtb3provided by RGD
Official Full Name: Rho-related BTB domain containing 3provided by RGD
Primary source: RGD:1311683
See related: EnsemblRapid:ENSRNOG00000012414 AllianceGenome:RGD:1311683
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within male gonad development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 150.3), Liver (RPKM 109.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (7094972..7201507, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (5363388..5419164, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (2627655..2683305, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU046895 (e-PCR)
- UniSTS:111034

RH143666 (e-PCR)
- UniSTS:232912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho-related BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107645.1 → NP_001101115.1 rho-related BTB domain-containing protein 3

See identical proteins and their annotated locations for NP_001101115.1

Status: PROVISIONAL

Source sequence(s)

CH473955

UniProtKB/TrEMBL

A6I4F2, A6I4F3, D3ZW90

Related

ENSRNOP00000016838.5, ENSRNOT00000016838.8

Conserved Domains (3) summary

smart00225
Location:421 → 518

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:413 → 515

BTB; BTB/POZ domain

cl21455
Location:34 → 174

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

7094972..7201507 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281692.1 → XP_063137762.1 rho-related BTB domain-containing protein 3 isoform X2
XM_039102150.2 → XP_038958078.1 rho-related BTB domain-containing protein 3 isoform X1

Conserved Domains (3) summary

cd18357
Location:236 → 393

BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)

cl38908
Location:410 → 428

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl38936
Location:34 → 174

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases