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    Vars2 valyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vars2provided by RGD
    Official Full Name
    valyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1303122
    See related
    EnsemblRapid:ENSRNOG00000000833 AllianceGenome:RGD:1303122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Varsl; Vars2l
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 43.2), Adrenal (RPKM 43.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vars2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3081869..3092907)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3077132..3087994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3588462..3599514)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene discoidin domain receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC134483850 Neighboring gene general transcription factor 2H subunit 4 Neighboring gene surfactant associated 2 Neighboring gene mucin like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • KIAA1885

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables valine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    valine--tRNA ligase, mitochondrial
    Names
    valRS
    valyl-tRNA synthetase 2, mitochondrial (putative)
    valyl-tRNA synthetase, mitochondrial
    XP_063135159.1
    XP_063135160.1
    XP_063135161.1
    XP_063135162.1
    XP_063135163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429116.1 → NP_001416045.1  valine--tRNA ligase, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q6MG21

    2. NM_001429117.1 → NP_001416046.1  valine--tRNA ligase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q6MG21

    RNA

    1. NR_190585.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3081869..3092907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279089.1 → XP_063135159.1  valine--tRNA ligase, mitochondrial isoform X1

      Related
      ENSRNOP00000098217.2, ENSRNOT00000048103.7

    2. XM_063279093.1 → XP_063135163.1  valine--tRNA ligase, mitochondrial isoform X5

    3. XM_063279091.1 → XP_063135161.1  valine--tRNA ligase, mitochondrial isoform X3

    4. XM_063279092.1 → XP_063135162.1  valine--tRNA ligase, mitochondrial isoform X4

    5. XM_063279090.1 → XP_063135160.1  valine--tRNA ligase, mitochondrial isoform X2

    RNA

    1. XR_010060663.1 RNA Sequence

    2. XR_010060661.1 RNA Sequence

    3. XR_010060662.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG21.1 GenPept UniProtKB/Swiss-Prot:Q6MG21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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