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    Pde11a phosphodiesterase 11A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde11aprovided by RGD
    Official Full Name
    phosphodiesterase 11Aprovided by RGD
    Primary source
    RGD:621793
    See related
    EnsemblRapid:ENSRNOG00000024457 AllianceGenome:RGD:621793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in negative regulation of cAMP/PKA signal transduction and negative regulation of cGMP-mediated signaling. Located in perikaryon. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 2. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 28.2), Kidney (RPKM 22.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde11a in Genome Data Viewer
    Location:
    3q23-q24
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (81320822..81704397, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (60913562..61297154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (62818502..63211843, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 70A2 Neighboring gene intraflagellar transport 70A1 Neighboring gene uncharacterized LOC120101579 Neighboring gene uncharacterized LOC134486390 Neighboring gene uncharacterized LOC120101580 Neighboring gene acidic nuclear phosphoprotein 32 family member A, pseudogene 1 Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene oxysterol binding protein-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Weeks JL 2nd, et al. Biochemistry, 2007 Sep 11. PMID 17696499
    2. Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants. Yuasa K, et al. Eur J Biochem, 2001 Aug. PMID 11502204
    3. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system. Kruse LS, et al. Brain Res, 2009 Jul 24. PMID 19445908
    4. Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants. Virbasius JV, et al. J Biol Chem, 1988 May 15. PMID 2834389
    5. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. Matthiesen K, et al. Biochem J, 2009 Oct 12. PMID 19689430

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cAMP/PKA signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
    Names
    cAMP and cGMP phosphodiesterase 11A
    NP_001120952.1
    NP_001120953.1
    NP_543169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127480.2 → NP_001120952.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3

      See identical proteins and their annotated locations for NP_001120952.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (3), also known as PDE11A3, contains a distinct 5' UTR and 5' coding region, compared to variant 4. The resulting isoform (3) contains a shorter and distinct N-terminus, compared to isoform 4.
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8VID6
      Conserved Domains (2) summary
      smart00065
      Location:152 → 318
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:413 → 648
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001127481.3 → NP_001120953.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 2

      See identical proteins and their annotated locations for NP_001120953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also known as PDE11A2, contains a distinct 5' UTR and 5' coding region, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 4.
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8VID6
      Related
      ENSRNOP00000048657.2, ENSRNOT00000045862.4
      Conserved Domains (2) summary
      smart00065
      Location:48 → 214
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:309 → 544
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_080893.2 → NP_543169.1  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4

      See identical proteins and their annotated locations for NP_543169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), also known as PDE11A4, represents the longest transcript and encodes the longest protein (isoform 4).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8VID6, Q8VID7, Q8VID8
      UniProtKB/TrEMBL
      A0A8L2Q3C3
      Related
      ENSRNOP00000008300.6, ENSRNOT00000008301.8
      Conserved Domains (2) summary
      smart00065
      Location:217 → 380
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:663 → 898
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      81320822..81704397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VID6.1 GenPept UniProtKB/Swiss-Prot:Q8VID6

    Gene LinkOut

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