Pak5 p21 (RAC1) activated kinase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pak5provided by RGD
Official Full Name: p21 (RAC1) activated kinase 5provided by RGD
Primary source: RGD:1312009
See related: EnsemblRapid:ENSRNOG00000005509 AllianceGenome:RGD:1312009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pak7; PAK-5; PAK-7
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to starvation; intracellular signal transduction; and regulation of MAPK cascade. Predicted to act upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be active in cytoplasm and synapse. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 102.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (143848404..144156674, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (123395678..123703967, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (129042232..129357512, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D3Rat254 (e-PCR), detects polymorphism
- UniSTS:227639

RH137907 (e-PCR)
- UniSTS:219994

BF400086 (e-PCR)
- UniSTS:244828

BF397900 (e-PCR)
- UniSTS:246380

RH144603 (e-PCR)
- UniSTS:233848

RH137684 (e-PCR)
- UniSTS:219771

D3Rat156 (e-PCR), detects polymorphism
- UniSTS:227562

BF405154 (e-PCR)
- UniSTS:247804

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase PAK 5

Names: p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; serine/threonine-protein kinase PAK 7

NP_001101251.1

EC 2.7.11.1

XP_017447245.1

EC 2.7.11.1

XP_017447246.1

EC 2.7.11.1

XP_038960946.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107781.2 → NP_001101251.1 serine/threonine-protein kinase PAK 5

See identical proteins and their annotated locations for NP_001101251.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D4A280

Related

ENSRNOP00000007410.3, ENSRNOT00000007410.6

Conserved Domains (2) summary

cd06658
Location:425 → 716

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
NM_001434030.1 → NP_001420959.1 serine/threonine-protein kinase PAK 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D4A280
NM_001434031.1 → NP_001420960.1 serine/threonine-protein kinase PAK 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D4A280

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

143848404..144156674 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591756.3 → XP_017447245.1 serine/threonine-protein kinase PAK 5 isoform X1

Conserved Domains (2) summary

cd06658
Location:425 → 716

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_039105018.2 → XP_038960946.1 serine/threonine-protein kinase PAK 5 isoform X1

Conserved Domains (2) summary

cd06658
Location:425 → 716

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
XM_017591757.3 → XP_017447246.1 serine/threonine-protein kinase PAK 5 isoform X1

UniProtKB/Swiss-Prot

D4A280

Conserved Domains (2) summary

cd06658
Location:425 → 716

STKc_PAK5; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5

cd01093
Location:9 → 55

CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...