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    Kbtbd8 kelch repeat and BTB domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kbtbd8provided by RGD
    Official Full Name
    kelch repeat and BTB domain containing 8provided by RGD
    Primary source
    RGD:1563166
    See related
    EnsemblRapid:ENSRNOG00000013390 AllianceGenome:RGD:1563166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563166
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in mesenchymal cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein monoubiquitination. Predicted to be located in Golgi apparatus and spindle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD8 (kelch repeat and BTB domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 48.4), Brain (RPKM 43.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kbtbd8 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (129232781..129245608)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127675967..127688785)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (127164728..127177537)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486618 Neighboring gene proteasome 20S subunit beta 3, pseudogene 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 45 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell-fate determination by ubiquitin-dependent regulation of translation. Werner A, et al. Nature, 2015 Sep 24. PMID 26399832, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural crest formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 8
    Names
    kelch repeat and BTB (POZ) domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109250.3 → NP_001102720.2  kelch repeat and BTB domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      BC160902, CR467699
      UniProtKB/TrEMBL
      F8WFZ9
      Related
      ENSRNOP00000017889.5, ENSRNOT00000017889.9
      Conserved Domains (4) summary
      PHA03098
      Location:50 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 376
      Kelch; KELCH repeat [structural motif]
      cd18274
      Location:27 → 155
      BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
      cd18483
      Location:147 → 243
      BACK_KBTBD8; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      129232781..129245608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236932.4 → XP_006236994.1  kelch repeat and BTB domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006236994.1

      UniProtKB/Swiss-Prot
      B1H285
      Related
      ENSRNOP00000104815.1, ENSRNOT00000131208.1
      Conserved Domains (4) summary
      PHA03098
      Location:24 → 490
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:304 → 350
      Kelch; KELCH repeat [structural motif]
      cd18274
      Location:1 → 129
      BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
      cl28903
      Location:121 → 217
      BACK; BACK (BTB and C-terminal Kelch) domain

    2. XM_039108196.2 → XP_038964124.1  kelch repeat and BTB domain-containing protein 8 isoform X1

      UniProtKB/Swiss-Prot
      B1H285
      Conserved Domains (4) summary
      PHA03098
      Location:24 → 490
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:304 → 350
      Kelch; KELCH repeat [structural motif]
      cd18274
      Location:1 → 129
      BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
      cl28903
      Location:121 → 217
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1H285.1 GenPept UniProtKB/Swiss-Prot:B1H285

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