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    P3h3 prolyl 3-hydroxylase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297595, updated on 27-Nov-2024

    Summary

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    Official Symbol
    P3h3provided by RGD
    Official Full Name
    prolyl 3-hydroxylase 3provided by RGD
    Primary source
    RGD:1305699
    See related
    EnsemblRapid:ENSRNOG00000071218 AllianceGenome:RGD:1305699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Leprel2
    Summary
    Predicted to enable procollagen-proline 3-dioxygenase activity. Predicted to be involved in collagen biosynthetic process; negative regulation of cell population proliferation; and peptidyl-lysine hydroxylation. Predicted to be part of catalytic complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P3H3 (prolyl 3-hydroxylase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 108.4), Lung (RPKM 98.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P3h3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159332514..159348428, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157646242..157662035, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157359331..157375186, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 5 Neighboring gene cell division cycle associated 3 Neighboring gene G protein subunit beta 3 Neighboring gene uncharacterized LOC120102385 Neighboring gene G protein-coupled receptor 162 Neighboring gene Cd4 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. Hudson DM, et al. J Biol Chem, 2017 Mar 3. PMID 28115524, Free PMC Article
    2. The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Shah R, et al. Br J Cancer, 2009 May 19. PMID 19436308, Free PMC Article
    3. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. Heard ME, et al. PLoS Genet, 2016 Apr. PMID 27119146, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189333

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolyl 3-hydroxylase 3
    Names
    leprecan-like 2
    NP_001100090.3
    XP_038963377.1
    XP_038963378.1
    XP_063141978.1
    XP_063141979.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106620.3 → NP_001100090.3  prolyl 3-hydroxylase 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0AA76ENW5
      Related
      ENSRNOP00000098013.1, ENSRNOT00000120322.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159332514..159348428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107449.2 → XP_038963377.1  prolyl 3-hydroxylase 3 isoform X1

      Related
      ENSRNOP00000100497.1, ENSRNOT00000135675.1
      Conserved Domains (1) summary
      cl21496
      Location:471 → 633
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_063285908.1 → XP_063141978.1  prolyl 3-hydroxylase 3 isoform X2

    3. XM_063285909.1 → XP_063141979.1  prolyl 3-hydroxylase 3 isoform X3

    4. XM_039107450.2 → XP_038963378.1  prolyl 3-hydroxylase 3 isoform X4

    RNA

    1. XR_353597.5 RNA Sequence

    2. XR_005503202.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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