Cd320 CD320 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd320provided by RGD
Official Full Name: CD320 moleculeprovided by RGD
Primary source: RGD:1305860
See related: AllianceGenome:RGD:1305860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TCblR; RGD1305860
Summary: Predicted to enable several functions, including calcium ion binding activity; cobalamin binding activity; and low-density lipoprotein particle receptor activity. Predicted to be involved in several processes, including cholesterol homeostasis; cobalamin transport; and positive regulation of B cell activation. Predicted to act upstream of or within regulation of vitamin metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in early endosome and plasma membrane. Human ortholog(s) of this gene implicated in methylmalonic acidemia due to transcobalamin receptor defect. Orthologous to human CD320 (CD320 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 88.8), Kidney (RPKM 88.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (15328320..15334138)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (14626171..14631976)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (18700445..18706244)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables cobalamin binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in B cell costimulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cobalamin transport	ISO Inferred from Sequence Orthology more info
involved_in cobalamin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of vitamin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CD320 antigen

Names: CD320 antigen-like; transcobalamin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014201.2 → NP_001014223.1 CD320 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_001014223.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q5HZW5

UniProtKB/TrEMBL

A0A8I6AK05

Conserved Domains (1) summary

cd00112
Location:51 → 86

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
NM_001393847.1 → NP_001380776.1 CD320 antigen isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6AK05

Conserved Domains (1) summary

cd00112
Location:51 → 86

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

15328320..15334138

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241128.5 → XP_006241190.1 CD320 antigen isoform X1

Conserved Domains (1) summary

cd00112
Location:51 → 86

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...