Mtbp MDM2 binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mtbpprovided by RGD
Full Name: MDM2 binding proteinprovided by RGD
Primary source: RGD:1565672
See related: EnsemblRapid:ENSRNOG00000004412 AllianceGenome:RGD:1565672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565672
Summary: Predicted to be involved in protein localization to kinetochore and traversing start control point of mitotic cell cycle. Predicted to act upstream of or within negative regulation of cell population proliferation and negative regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in kinetochore. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 40.4), Thymus (RPKM 33.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (88862939..88945491)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (86973215..87055775)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (95309928..95392418)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in traversing start control point of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within traversing start control point of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mdm2-binding protein

Names: Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130717.2 → NP_001124189.2 mdm2-binding protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HRH7, D4AB60

Related

ENSRNOP00000005887.5, ENSRNOT00000005887.6

Conserved Domains (3) summary

pfam14918
Location:1 → 270

MTBP_N; MDM2-binding

pfam14919
Location:294 → 633

MTBP_mid; MDM2-binding

pfam14920
Location:637 → 891

MTBP_C; MDM2-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

88862939..88945491

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241656.5 → XP_006241718.1 mdm2-binding protein isoform X2

See identical proteins and their annotated locations for XP_006241718.1

UniProtKB/TrEMBL

A6HRH7, D4AB60

Related

ENSRNOP00000100117.1, ENSRNOT00000141688.1

Conserved Domains (3) summary

pfam14918
Location:1 → 270

MTBP_N; MDM2-binding

pfam14919
Location:294 → 633

MTBP_mid; MDM2-binding

pfam14920
Location:637 → 867

MTBP_C; MDM2-binding
XM_039079751.2 → XP_038935679.1 mdm2-binding protein isoform X3

UniProtKB/TrEMBL

A6HRH7, D4AB60

Conserved Domains (3) summary

pfam14918
Location:1 → 270

MTBP_N; MDM2-binding

pfam14919
Location:294 → 633

MTBP_mid; MDM2-binding

pfam14920
Location:637 → 802

MTBP_C; MDM2-binding
XM_063264120.1 → XP_063120190.1 mdm2-binding protein isoform X1

UniProtKB/TrEMBL

A6HRH7, D4AB60
XM_039079754.2 → XP_038935682.2 mdm2-binding protein isoform X4