Eif3d eukaryotic translation initiation factor 3, subunit D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif3dprovided by RGD
Official Full Name: eukaryotic translation initiation factor 3, subunit Dprovided by RGD
Primary source: RGD:1303255
See related: EnsemblRapid:ENSRNOG00000005804 AllianceGenome:RGD:1303255
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eif3s7
Summary: Predicted to enable mRNA cap binding activity and translation initiation factor activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; cytoplasmic translational initiation; and viral translational termination-reinitiation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Predicted to be active in synapse. Orthologous to human EIF3D (eukaryotic translation initiation factor 3 subunit D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 361.3), Adrenal (RPKM 335.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111420351..111432761, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109539795..109552184, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119188189..119200578, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128317 (e-PCR)
- UniSTS:211625

RH125745 (e-PCR)
- UniSTS:162500

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA cap binding	ISO Inferred from Sequence Orthology more info
enables mRNA cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cap-dependent translational initiation	IEA Inferred from Electronic Annotation more info
involved_in cap-dependent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in cap-dependent translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in formation of cytoplasmic translation initiation complex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral translational termination-reinitiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit D

Names: eIF-3-zeta; eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3, subunit 7 (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004283.1 → NP_001004283.1 eukaryotic translation initiation factor 3 subunit D

See identical proteins and their annotated locations for NP_001004283.1

Status: PROVISIONAL

Source sequence(s)

BC079005

UniProtKB/Swiss-Prot

Q6AYK8

UniProtKB/TrEMBL

A0A8I6GLW5

Related

ENSRNOP00000032361.2, ENSRNOT00000029753.5

Conserved Domains (1) summary

pfam05091
Location:4 → 521

eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111420351..111432761 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241938.5 → XP_006242000.1 eukaryotic translation initiation factor 3 subunit D isoform X1

See identical proteins and their annotated locations for XP_006242000.1

UniProtKB/Swiss-Prot

Q6AYK8

UniProtKB/TrEMBL

A0A8I6GLW5

Conserved Domains (1) summary

pfam05091
Location:4 → 521

eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)