Slc4a3 solute carrier family 4 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc4a3provided by RGD
Official Full Name: solute carrier family 4 member 3provided by RGD
Primary source: RGD:3712
See related: EnsemblRapid:ENSRNOG00000020138 AllianceGenome:RGD:3712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ae3; Aep3
Summary: Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of cardiac muscle cell action potential; and regulation of pH. Predicted to act upstream of or within cardiac conduction. Located in plasma membrane. Orthologous to human SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 210.4), Brain (RPKM 75.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84484749..84497746)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (77036243..77053940)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82742207..82755119)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increase in AE(3) expression occurring during SQS pretreatment was almost completely abolished.
Title: Sasanquasaponin up-regulates anion exchanger 3 expression and elicits cardioprotection via NO/RAS/ERK1/2 pathway.
AE(3) is required for SQS to inhibit sI/R-induced elevation of [Cl(-)](i), which subsequently inhibited sI/R-induced Ca(2+) overload, ROS production, and cell apoptosis.
Title: Anion exchanger 3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl- concentration and to elicit cardioprotection.
Coexpression of carbonic anhydrase IX and SLC4A3 activated SLC4A3 mediated transport.
Title: Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144096 (e-PCR)
- UniSTS:233342

D9Mco24 (e-PCR)
- UniSTS:518821

D9Bro1 (e-PCR)
- UniSTS:240357

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	IEA Inferred from Electronic Annotation more info
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pH reduction	IEA Inferred from Electronic Annotation more info
involved_in pH reduction	ISO Inferred from Sequence Orthology more info
involved_in pH reduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anion exchange protein 3

Names: AE 3; B3RP-3; Solute carrier family 4, member 3, anion exchange protein 3; anion exchanger 3; band 3-related protein 3; neuronal band 3-like protein; solute carrier family 4 (anion exchanger), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017049.2 → NP_058745.2 anion exchange protein 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8

Conserved Domains (1) summary

TIGR00834
Location:321 → 1226

ae; anion exchange protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84484749..84497746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596279.3 → XP_017451768.1 anion exchange protein 3 isoform X1

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8

Conserved Domains (1) summary

TIGR00834
Location:321 → 1226

ae; anion exchange protein
XM_017596280.3 → XP_017451769.1 anion exchange protein 3 isoform X1

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8

Conserved Domains (1) summary

TIGR00834
Location:321 → 1226

ae; anion exchange protein
XM_017596277.3 → XP_017451766.1 anion exchange protein 3 isoform X1

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8

Related

ENSRNOP00000027337.1, ENSRNOT00000027337.5

Conserved Domains (1) summary

TIGR00834
Location:321 → 1226

ae; anion exchange protein
XM_017596276.3 → XP_017451765.1 anion exchange protein 3 isoform X1

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8

Conserved Domains (1) summary

TIGR00834
Location:321 → 1226

ae; anion exchange protein
XM_063266648.1 → XP_063122718.1 anion exchange protein 3 isoform X1

UniProtKB/Swiss-Prot

P23348

UniProtKB/TrEMBL

A6JW47, G3V8P8
XM_063266649.1 → XP_063122719.1 anion exchange protein 3 isoform X4
XM_039083028.2 → XP_038938956.1 anion exchange protein 3 isoform X2

UniProtKB/Swiss-Prot

P23348

Conserved Domains (1) summary

TIGR00834
Location:251 → 1156

ae; anion exchange protein
XM_063266650.1 → XP_063122720.1 anion exchange protein 3 isoform X4
XM_006245149.5 → XP_006245211.1 anion exchange protein 3 isoform X3

Conserved Domains (3) summary

TIGR00834
Location:124 → 1029

ae; anion exchange protein

pfam00955
Location:477 → 959

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:159 → 421

Band_3_cyto; Band 3 cytoplasmic domain
XM_063266651.1 → XP_063122721.1 anion exchange protein 3 isoform X5
XM_039083030.2 → XP_038938958.1 anion exchange protein 3 isoform X6

Conserved Domains (1) summary

cl26877
Location:1 → 736

Band_3_cyto; Band 3 cytoplasmic domain