Nkap NFKB activating protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nkapprovided by RGD
Official Full Name: NFKB activating proteinprovided by RGD
Primary source: RGD:1565955
See related: EnsemblRapid:ENSRNOG00000053813 AllianceGenome:RGD:1565955
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 2610020o08rik
Summary: Predicted to enable chromatin DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of alpha-beta T cell differentiation. Predicted to act upstream of or within hemopoiesis and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human NKAP (NFKB activating protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 109.9), Thymus (RPKM 88.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq35

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (121238714..121258360)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (116373031..116392677)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (123751196..123770595)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in granulocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NF-kappa-B-activating protein

Names: nuclear NF-kappaB activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024872.1 → NP_001020043.1 NF-kappa-B-activating protein

See identical proteins and their annotated locations for NP_001020043.1

Status: PROVISIONAL

Source sequence(s)

BC098011

UniProtKB/Swiss-Prot

Q4V7C9

UniProtKB/TrEMBL

A6JMH7

Related

ENSRNOP00000073123.2, ENSRNOT00000089883.3

Conserved Domains (2) summary

pfam06047
Location:306 → 407

SynMuv_product; Ras-induced vulval development antagonizt

pfam15692
Location:118 → 165

NKAP; NF-kappa-B-activating protein