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    Myo5b myosin VB [ Mus musculus (house mouse) ]

    Gene ID: 17919, updated on 4-Jan-2025

    Summary

    Official Symbol
    Myo5bprovided by MGI
    Official Full Name
    myosin VBprovided by MGI
    Primary source
    MGI:MGI:106598
    See related
    Ensembl:ENSMUSG00000025885 AllianceGenome:MGI:106598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1119
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; ionotropic glutamate receptor binding activity; and small GTPase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within protein transmembrane transport. Located in brush border. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system; genitourinary system; gut; heart; and skeletal muscle. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease and progressive familial intrahepatic cholestasis. Orthologous to human MYO5B (myosin VB). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in large intestine adult (RPKM 24.0), genital fat pad adult (RPKM 20.9) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myo5b in Genome Data Viewer
    Location:
    18 E2; 18 50.7 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74575435..74905769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74442364..74772698)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45011 Neighboring gene STARR-seq mESC enhancer starr_45012 Neighboring gene STARR-seq mESC enhancer starr_45013 Neighboring gene STARR-seq mESC enhancer starr_45014 Neighboring gene ribosomal protein S11 pseudogene Neighboring gene predicted gene 8987 Neighboring gene RIKEN cDNA 1700120E14 gene Neighboring gene predicted gene, 33090 Neighboring gene STARR-seq mESC enhancer starr_45015 Neighboring gene predicted gene, 52349 Neighboring gene STARR-seq mESC enhancer starr_45016 Neighboring gene predicted gene, 52348 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:74920293-74920490 Neighboring gene STARR-positive B cell enhancer ABC_E9985 Neighboring gene small Cajal body-specific RNA 17 Neighboring gene predicted gene, 41774 Neighboring gene predicted gene, 23119

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables actin binding  
    enables actin filament binding  
    enables actin filament binding  
    enables calmodulin binding  
    enables cytoskeletal motor activity  
    enables ionotropic glutamate receptor binding  
    enables microfilament motor activity  
    enables protein binding PubMed 
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in dendritic spine morphogenesis  
    involved_in endocytosis  
    involved_in endosomal transport  
    involved_in endosomal transport  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in neurotransmitter receptor transport, endosome to plasma membrane  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of dendrite morphogenesis  
    involved_in positive regulation of exosomal secretion  
    involved_in positive regulation of protein localization to plasma membrane  
    acts_upstream_of_or_within protein transmembrane transport PubMed 
    involved_in regulation of modification of postsynaptic structure  
    involved_in regulation of protein localization  
    involved_in synaptic vesicle recycling via endosome  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport in synapse  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in actin cytoskeleton  
    located_in apical cortex  
    located_in apical cortex  
    located_in brush border PubMed 
    is_active_in cytoplasm  
    located_in dendritic spine  
    is_active_in glutamatergic synapse  
    is_active_in membrane  
    part_of myosin complex  
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm  
    is_active_in postsynapse  
    is_active_in postsynaptic actin cytoskeleton  
    is_active_in postsynaptic recycling endosome membrane  
    part_of protein-containing complex  
    located_in recycling endosome  

    General protein information

    Preferred Names
    unconventional myosin-Vb
    Names
    myosin-Vb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201600.2NP_963894.1  unconventional myosin-Vb

      See identical proteins and their annotated locations for NP_963894.1

      Status: VALIDATED

      Source sequence(s)
      AC147992, AC148001, AC148002, AK033484, BQ557090, BU610647, BY245557, CD352410, CF741517, CJ052777, CV558709, DV655888
      Consensus CDS
      CCDS37858.1
      UniProtKB/Swiss-Prot
      P21271, Q148A3, Q69ZR6, Q811F6, Q91X59
      UniProtKB/TrEMBL
      G5E8G6
      Related
      ENSMUSP00000073790.7, ENSMUST00000074157.13
      Conserved Domains (8) summary
      smart00015
      Location:861881
      IQ; Calmodulin-binding motif
      smart00242
      Location:64761
      MYSc; Myosin. Large ATPases
      COG4942
      Location:11451435
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd15477
      Location:14441815
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:83750
      MYSc_Myo5; class V myosin, motor domain
      pfam07956
      Location:901993
      DUF1690; Protein of Unknown function (DUF1690)
      pfam08614
      Location:9791208
      ATG16; Autophagy protein 16 (ATG16)
      cl23720
      Location:9701060
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      74575435..74905769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525714.4XP_006525777.1  unconventional myosin-Vb isoform X1

      UniProtKB/TrEMBL
      G3X9Y9
      Conserved Domains (4) summary
      COG4942
      Location:11361449
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:111268
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14751846
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:83750
      MYSc_Myo5; class V myosin, motor domain
    2. XM_006525715.5XP_006525778.1  unconventional myosin-Vb isoform X2

      UniProtKB/Swiss-Prot
      P21271, Q148A3, Q69ZR6, Q811F6, Q91X59
      Conserved Domains (4) summary
      COG4942
      Location:11581448
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:191276
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14571828
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:91758
      MYSc_Myo5; class V myosin, motor domain
    3. XM_006525716.4XP_006525779.1  unconventional myosin-Vb isoform X3

      UniProtKB/Swiss-Prot
      P21271, Q148A3, Q69ZR6, Q811F6, Q91X59
      Conserved Domains (4) summary
      COG4942
      Location:11531443
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:191271
      COG5022; Myosin heavy chain [General function prediction only]
      cd15477
      Location:14521823
      Myo5b_CBD; Cargo binding domain of myosin 5b
      cd01380
      Location:91758
      MYSc_Myo5; class V myosin, motor domain
    4. XM_036161024.1XP_036016917.1  unconventional myosin-Vb isoform X4

      Conserved Domains (2) summary
      COG0419
      Location:25576
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd15477
      Location:561932
      Myo5b_CBD; Cargo binding domain of myosin 5b

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