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    MMP16 matrix metallopeptidase 16 [ Homo sapiens (human) ]

    Gene ID: 4325, updated on 10-Dec-2024

    Summary

    Official Symbol
    MMP16provided by HGNC
    Official Full Name
    matrix metallopeptidase 16provided by HGNC
    Primary source
    HGNC:HGNC:7162
    See related
    Ensembl:ENSG00000156103 MIM:602262; AllianceGenome:HGNC:7162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
    Expression
    Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MMP16 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (88032011..88327483, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (89155362..89450838, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (89044239..89339712, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901972 Neighboring gene uncharacterized LOC105375628 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:89100426-89101134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:89161441-89162125 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:89310134-89311333 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:89314920-89315534 Neighboring gene uncharacterized LOC105375630 Neighboring gene RNA, 5S ribosomal pseudogene 272 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:89471701-89472542 Neighboring gene uncharacterized LOC105375629 Neighboring gene RLIG1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1273 screens)

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp761D112

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in chondrocyte proliferation  
    involved_in collagen catabolic process  
    involved_in craniofacial suture morphogenesis  
    involved_in embryonic cranial skeleton morphogenesis  
    involved_in endochondral ossification  
    involved_in extracellular matrix organization  
    involved_in protein processing PubMed 
    involved_in protein processing PubMed 
    involved_in proteolysis PubMed 
    involved_in proteolysis PubMed 
    involved_in skeletal system development  
    Component Evidence Code Pubs
    located_in Golgi lumen  
    located_in cell surface  
    located_in extracellular matrix  
    is_active_in extracellular space  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    matrix metalloproteinase-16
    Names
    MMP-16
    MT-MMP 3
    MT3MMP
    MTMMP3
    Putative transmembrane protein C8orf57
    matrix metallopeptidase 16 (membrane-inserted)
    membrane-type matrix metalloproteinase 3
    membrane-type-3 matrix metalloproteinase
    NP_005932.2
    XP_024302922.1
    XP_054216455.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005941.5 → NP_005932.2  matrix metalloproteinase-16 precursor

      See identical proteins and their annotated locations for NP_005932.2

      Status: REVIEWED

      Source sequence(s)
      AC037450, AL832595, D83646, DA575789
      Consensus CDS
      CCDS6246.1
      UniProtKB/Swiss-Prot
      B2RAN7, P51512, Q14824, Q52H48
      Related
      ENSP00000286614.6, ENST00000286614.11
      Conserved Domains (5) summary
      PHA03247
      Location:292 → 338
      PHA03247; large tegument protein UL36; Provisional
      cd00094
      Location:340 → 532
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:126 → 291
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 96
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:538 → 607
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      88032011..88327483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447154.2 → XP_024302922.1  matrix metalloproteinase-16 isoform X1

      Conserved Domains (4) summary
      cd00094
      Location:77 → 269
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam11857
      Location:274 → 344
      DUF3377; Domain of unknown function (DUF3377)
      cl26464
      Location:29 → 75
      Atrophin-1; Atrophin-1 family
      cl27698
      Location:1 → 28
      Peptidase_M10; Matrixin

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      89155362..89450838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360480.1 → XP_054216455.1  matrix metalloproteinase-16 isoform X1

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