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    PLXNB2 plexin B2 [ Homo sapiens (human) ]

    Gene ID: 23654, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PLXNB2provided by HGNC
    Official Full Name
    plexin B2provided by HGNC
    Primary source
    HGNC:HGNC:9104
    See related
    Ensembl:ENSG00000196576 MIM:604293; AllianceGenome:HGNC:9104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3
    Summary
    Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLXNB2 in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50274979..50307646, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50781981..50815405, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50713408..50746075, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50697131-50697703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50698428-50698928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50700498-50701229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13964 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50710106-50710645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50710646-50711186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13968 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50720546-50721745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50738869-50739425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50739426-50739982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:50743729-50744928 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50745236-50745386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50753063-50753811 Neighboring gene uncharacterized LOC105373096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50755814-50756314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50756315-50756815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50759389-50759889 Neighboring gene DENN domain containing 6B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13975 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50770723-50770912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50780464-50781110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13978 Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19318 Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability. Smith CEL, et al. J Med Genet, 2024 Jun 20. PMID 38458752, Free PMC Article
    2. Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors. Shinoura N, et al. Cancer Lett, 1995 Mar 2. PMID 7889532
    3. Plexin-B2 in psoriasis; a clinical and immunohistochemical study. Hemida AS, et al. J Immunoassay Immunochem, 2020 Jul 3. PMID 32186222
    4. Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia. Guo Z, et al. Mol Biol Rep, 2023 Oct. PMID 37632633
    5. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics. Huang Y, et al. Commun Biol, 2021 Jan 29. PMID 33514835, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo interaction screening reveals liver-derived constraints to metastasis.
      Title: In vivo interaction screening reveals liver-derived constraints to metastasis.
    2. Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
      Title: Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.
    3. Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
      Title: Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
    4. Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
      Title: Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
    5. CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
      Title: CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
    6. Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
      Title: Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
    7. Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
      Title: Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
    8. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
      Title: Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
    9. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
      Title: Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
    10. Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
      Title: Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0315

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in excitatory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plexin-B2
    Names
    ferroptosis-associated lncRNA

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376864.1 → NP_001363793.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Conserved Domains (7) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1350 → 1883
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain

    2. NM_001376865.1 → NP_001363794.1  plexin-B2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:918 → 1004
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:826 → 917
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:782 → 822
      PSI; Plexin repeat
      pfam08337
      Location:1294 → 1827
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:1006 → 1116
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    3. NM_001376866.1 → NP_001363795.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Related
      ENSP00000409171.1, ENST00000449103.5
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    4. NM_001376867.1 → NP_001363796.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    5. NM_001376868.1 → NP_001363797.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    6. NM_001376869.1 → NP_001363798.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    7. NM_001376870.1 → NP_001363799.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    8. NM_001376871.1 → NP_001363800.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    9. NM_001376872.1 → NP_001363801.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    10. NM_001376873.1 → NP_001363802.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    11. NM_001376874.1 → NP_001363803.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    12. NM_001376875.1 → NP_001363804.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    13. NM_001376876.1 → NP_001363805.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    14. NM_001376877.1 → NP_001363806.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    15. NM_001376878.1 → NP_001363807.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    16. NM_001376879.1 → NP_001363808.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    17. NM_001376880.1 → NP_001363809.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    18. NM_001376881.1 → NP_001363810.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    19. NM_001376882.1 → NP_001363811.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    20. NM_001376883.1 → NP_001363812.1  plexin-B2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1263 → 1796
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    21. NM_001376884.1 → NP_001363813.1  plexin-B2 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      cd12792
      Location:1271 → 1811
      RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    22. NM_001376885.1 → NP_001363814.1  plexin-B2 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      cd12792
      Location:1271 → 1811
      RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    23. NM_001376886.1 → NP_001363815.1  plexin-B2 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL022328, BX649592, CT010163
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:864 → 950
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:772 → 863
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:728 → 768
      PSI; Plexin repeat
      pfam08337
      Location:1240 → 1773
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:952 → 1062
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    24. NM_012401.4 → NP_036533.2  plexin-B2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_036533.2

      Status: VALIDATED

      Source sequence(s)
      AB002313, AL022328, BC000221, BX649592, CT010163
      Consensus CDS
      CCDS43035.1
      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7
      Related
      ENSP00000352288.4, ENST00000359337.9
      Conserved Domains (8) summary
      cd11276
      Location:27 → 467
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      smart00423
      Location:468 → 518
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:895 → 981
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:803 → 894
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:759 → 799
      PSI; Plexin repeat
      pfam08337
      Location:1271 → 1804
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:526 → 613
      TIG_plexin; TIG domain
      cl15674
      Location:983 → 1093
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50274979..50307646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441264.1 → XP_047297220.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    2. XM_011530682.3 → XP_011528984.1  plexin-B2 isoform X1

      Conserved Domains (6) summary
      cd11276
      Location:90 → 530
      Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
      cd01179
      Location:958 → 1044
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:866 → 957
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:532 → 580
      PSI; Plexin repeat
      pfam01833
      Location:1046 → 1154
      TIG; IPT/TIG domain
      pfam08337
      Location:1334 → 1868
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain

    3. XM_047441263.1 → XP_047297219.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    4. XM_047441262.1 → XP_047297218.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    5. XM_047441261.1 → XP_047297217.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    6. XM_047441266.1 → XP_047297222.1  plexin-B2 isoform X4

      UniProtKB/TrEMBL
      Q3LIB1
      Related
      ENST00000479701.5

    7. XM_047441265.1 → XP_047297221.1  plexin-B2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50781981..50815405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325401.1 → XP_054181376.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    2. XM_054325399.1 → XP_054181374.1  plexin-B2 isoform X1

    3. XM_054325402.1 → XP_054181377.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    4. XM_054325400.1 → XP_054181375.1  plexin-B2 isoform X2

      UniProtKB/Swiss-Prot
      A6QRH0, O15031, Q7KZU3, Q9BSU7

    5. XM_054325404.1 → XP_054181379.1  plexin-B2 isoform X4

      UniProtKB/TrEMBL
      Q3LIB1

    6. XM_054325403.1 → XP_054181378.1  plexin-B2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15031.3 GenPept UniProtKB/Swiss-Prot:O15031

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