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    DDX25 DEAD-box helicase 25 [ Homo sapiens (human) ]

    Gene ID: 29118, updated on 3-Dec-2024

    Summary

    Official Symbol
    DDX25provided by HGNC
    Official Full Name
    DEAD-box helicase 25provided by HGNC
    Primary source
    HGNC:HGNC:18698
    See related
    Ensembl:ENSG00000109832 MIM:607663; AllianceGenome:HGNC:18698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRTH
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 40.9) See more
    Orthologs
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    Genomic context

    See DDX25 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125903328..125928843)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125932197..125957695)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125773223..125798738)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4044 Neighboring gene HYLS1 centriolar and ciliogenesis associated Neighboring gene pseudouridine synthase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125802853-125803806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125805158-125805722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4045 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene cell adhesion associated, oncogene regulated Neighboring gene VISTA enhancer hs1641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4046

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromatoid body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX25
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 25
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
    DEAD box protein 25
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25
    epididymis secretory sperm binding protein
    gonadotropin-regulated testicular RNA helicase
    NP_001317367.1
    NP_037396.3
    XP_047282805.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330438.2NP_001317367.1  ATP-dependent RNA helicase DDX25 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL520666, AL534333, AP000842
      Consensus CDS
      CCDS81646.1
      UniProtKB/TrEMBL
      A0A384NYS3, E9PR46
      Related
      ENSP00000490224.1, ENST00000525943.1
      Conserved Domains (2) summary
      cd18787
      Location:198334
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
      cl28899
      Location:1194
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    2. NM_013264.5NP_037396.3  ATP-dependent RNA helicase DDX25 isoform 1

      See identical proteins and their annotated locations for NP_037396.3

      Status: REVIEWED

      Source sequence(s)
      AF155140, AL563479, AP000842, BC050360
      Consensus CDS
      CCDS44766.1
      UniProtKB/Swiss-Prot
      B2R6Z0, Q5XVN2, Q86W81, Q8IYP1, Q9UHL0
      UniProtKB/TrEMBL
      J3QL17
      Related
      ENSP00000263576.6, ENST00000263576.11
      Conserved Domains (3) summary
      smart00487
      Location:112315
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:311447
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:111301
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      125903328..125928843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426849.1XP_047282805.1  ATP-dependent RNA helicase DDX25 isoform X1

      UniProtKB/TrEMBL
      B4DHI6, J3QL17
      Related
      ENSP00000463333.1, ENST00000530414.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      125932197..125957695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)