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    ZMYND15 zinc finger MYND-type containing 15 [ Homo sapiens (human) ]

    Gene ID: 84225, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZMYND15provided by HGNC
    Official Full Name
    zinc finger MYND-type containing 15provided by HGNC
    Primary source
    HGNC:HGNC:20997
    See related
    Ensembl:ENSG00000141497 MIM:614312; AllianceGenome:HGNC:20997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGF14
    Summary
    This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
    Expression
    Biased expression in testis (RPKM 15.6), lung (RPKM 3.5) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZMYND15 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4739833..4746119)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4629276..4635789)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4643128..4649414)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11545 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47220 Neighboring gene arrestin beta 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4621547-4622746 Neighboring gene MPRA-validated peak2699 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4634559-4635378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4641736-4642641 Neighboring gene mediator complex subunit 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4642642-4643546 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4667359-4667521 Neighboring gene transmembrane 4 L six family member 5 Neighboring gene vitelline membrane outer layer 1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434N127

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger MYND domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034160.1 RefSeqGene

      Range
      4819..11099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136046.3NP_001129518.1  zinc finger MYND domain-containing protein 15 isoform 1

      See identical proteins and their annotated locations for NP_001129518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC091153, AK302181, DB453494
      Consensus CDS
      CCDS45584.1
      UniProtKB/Swiss-Prot
      B4DXY5, I3L296, Q9H091
      Related
      ENSP00000391742.1, ENST00000433935.6
      Conserved Domains (1) summary
      pfam01753
      Location:313359
      zf-MYND; MYND finger
    2. NM_001267822.1NP_001254751.1  zinc finger MYND domain-containing protein 15 isoform 3

      See identical proteins and their annotated locations for NP_001254751.1

      Status: REVIEWED

      Source sequence(s)
      AA937353, AK302181, BC067296, DB453494
      Consensus CDS
      CCDS58506.1
      UniProtKB/Swiss-Prot
      Q9H091
      Related
      ENSP00000269289.6, ENST00000269289.10
      Conserved Domains (1) summary
      pfam01753
      Location:313359
      zf-MYND; MYND finger
    3. NM_032265.2NP_115641.1  zinc finger MYND domain-containing protein 15 isoform 2

      See identical proteins and their annotated locations for NP_115641.1

      Status: REVIEWED

      Source sequence(s)
      AA937353, AC091153, AL136893, DB453494
      Consensus CDS
      CCDS11053.1
      UniProtKB/Swiss-Prot
      Q9H091
      Related
      ENSP00000465435.1, ENST00000592813.5
      Conserved Domains (1) summary
      pfam01753
      Location:313359
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4739833..4746119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025218.2XP_016880707.2  zinc finger MYND domain-containing protein 15 isoform X3

    2. XM_047436923.1XP_047292879.1  zinc finger MYND domain-containing protein 15 isoform X1

    3. XM_047436924.1XP_047292880.1  zinc finger MYND domain-containing protein 15 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4629276..4635789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317542.1XP_054173517.1  zinc finger MYND domain-containing protein 15 isoform X2

    2. XM_054317543.1XP_054173518.1  zinc finger MYND domain-containing protein 15 isoform X3