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    SLC37A1 solute carrier family 37 member 1 [ Homo sapiens (human) ]

    Gene ID: 54020, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC37A1provided by HGNC
    Official Full Name
    solute carrier family 37 member 1provided by HGNC
    Primary source
    HGNC:HGNC:11024
    See related
    Ensembl:ENSG00000160190 MIM:608094; AllianceGenome:HGNC:11024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G3PP; SPX1
    Summary
    The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in duodenum (RPKM 9.6), small intestine (RPKM 8.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC37A1 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (42499622..42581426)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40889339..40971074)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43919732..44001536)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18521 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43912470-43913669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43919416-43919916 Neighboring gene radial spoke head component 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43932366-43933088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43933089-43933811 Neighboring gene RSPH1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43940701-43941202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43941203-43941702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18523 Neighboring gene uncharacterized LOC107987299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43960552-43961217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43962233-43963163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43965367-43965904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43965905-43966440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43985802-43986722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43991832-43992575 Neighboring gene uncharacterized LOC101928212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13349 Neighboring gene VISTA enhancer hs2248 Neighboring gene MPRA-validated peak4415 silencer Neighboring gene long intergenic non-protein coding RNA 1671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44037913-44038824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44057507-44058403 Neighboring gene uncharacterized LOC101928255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44072695-44073416 Neighboring gene phosphodiesterase 9A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Bartoloni L, et al. Genomics, 2000 Dec 1. PMID 11112347
    2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. Pan CJ, et al. PLoS One, 2011. PMID 21949678, Free PMC Article
    3. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Carroll JS, et al. Cell, 2005 Jul 15. PMID 16009131
    4. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. Pope SN, et al. J Steroid Biochem Mol Biol, 2005 Feb. PMID 15862967
    5. Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. Liu H, et al. J Pathol, 2019 Aug. PMID 30945288

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22340

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose-6-phosphate transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A1
    Names
    G-3-P permease
    G-3-P transporter
    glycerol-3-phosphate permease
    glycerol-3-phosphate transporter
    solute carrier family 37 (glucose-6-phosphate transporter), member 1
    solute carrier family 37 (glycerol-3-phosphate transporter), member 1
    sugar-phosphate exchange protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033931.1 RefSeqGene

      Range
      4991..86795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320537.2 → NP_001307466.1  glucose-6-phosphate exchanger SLC37A1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and is inferred to be translated from a downstream start codon via ribosomal leaky scanning. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF311320, AP001625, BI912541, BM550728, DA755019
      Consensus CDS
      CCDS13689.1
      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1
      Related
      ENSP00000344648.2, ENST00000352133.3
      Conserved Domains (2) summary
      cd06174
      Location:98 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:20 → 519
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    2. NM_018964.4 → NP_061837.3  glucose-6-phosphate exchanger SLC37A1

      See identical proteins and their annotated locations for NP_061837.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ269529, AL355683, AP001625, AW466890, BI912541
      Consensus CDS
      CCDS13689.1
      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1
      Related
      ENSP00000381383.3, ENST00000398341.7
      Conserved Domains (2) summary
      cd06174
      Location:98 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:20 → 519
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      42499622..42581426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440843.1 → XP_047296799.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    2. XM_017028379.2 → XP_016883868.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1
      Conserved Domains (2) summary
      cd06174
      Location:98 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:20 → 519
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    3. XM_047440842.1 → XP_047296798.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    4. XM_017028377.2 → XP_016883866.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1
      Conserved Domains (2) summary
      cd06174
      Location:98 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:20 → 519
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    5. XM_017028381.2 → XP_016883870.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

    6. XM_047440845.1 → XP_047296801.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    7. XM_047440849.1 → XP_047296805.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1

    8. XM_047440844.1 → XP_047296800.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    9. XM_017028380.2 → XP_016883869.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

      UniProtKB/Swiss-Prot
      D3DSJ7, P57057, Q9HAQ1
      Conserved Domains (2) summary
      cd06174
      Location:98 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:20 → 519
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    10. XM_047440850.1 → XP_047296806.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

    11. XM_047440846.1 → XP_047296802.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    12. XM_047440848.1 → XP_047296804.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    13. XM_017028383.2 → XP_016883872.2  glucose-6-phosphate exchanger SLC37A1 isoform X4

    14. XM_047440847.1 → XP_047296803.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    15. XM_011529614.4 → XP_011527916.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

      Conserved Domains (2) summary
      cd06174
      Location:129 → 489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:51 → 543
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    16. XM_011529615.3 → XP_011527917.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

      Conserved Domains (2) summary
      cd06174
      Location:129 → 544
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG2271
      Location:51 → 550
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    17. XM_017028376.3 → XP_016883865.1  glucose-6-phosphate exchanger SLC37A1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      40889339..40971074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324574.1 → XP_054180549.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    2. XM_054324585.1 → XP_054180560.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    3. XM_054324589.1 → XP_054180564.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

    4. XM_054324579.1 → XP_054180554.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    5. XM_054324586.1 → XP_054180561.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    6. XM_054324590.1 → XP_054180565.1  glucose-6-phosphate exchanger SLC37A1 isoform X7

    7. XM_054324580.1 → XP_054180555.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    8. XM_054324587.1 → XP_054180562.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    9. XM_054324575.1 → XP_054180550.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    10. XM_054324576.1 → XP_054180551.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

    11. XM_054324588.1 → XP_054180563.1  glucose-6-phosphate exchanger SLC37A1 isoform X6

    12. XM_054324582.1 → XP_054180557.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    13. XM_054324583.1 → XP_054180558.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    14. XM_054324581.1 → XP_054180556.1  glucose-6-phosphate exchanger SLC37A1 isoform X4

    15. XM_054324577.1 → XP_054180552.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

    16. XM_054324578.1 → XP_054180553.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

    17. XM_054324584.1 → XP_054180559.1  glucose-6-phosphate exchanger SLC37A1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57057.2 GenPept UniProtKB/Swiss-Prot:P57057

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