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    CRACD capping protein inhibiting regulator of actin dynamics [ Homo sapiens (human) ]

    Gene ID: 57482, updated on 3-Dec-2024

    Summary

    Official Symbol
    CRACDprovided by HGNC
    Official Full Name
    capping protein inhibiting regulator of actin dynamicsprovided by HGNC
    Primary source
    HGNC:HGNC:29219
    See related
    Ensembl:ENSG00000109265 MIM:618327; AllianceGenome:HGNC:29219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRAD; KIAA1211
    Summary
    Involved in negative regulation of barbed-end actin filament capping. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CRACD in Genome Data Viewer
    Location:
    4q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (56049098..56330609)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59537287..59818577)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56915264..57196775)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377663 Neighboring gene exocyst complex component 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:56786864-56788063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21575 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:56814688-56815652 Neighboring gene uncharacterized LOC124900705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21576 Neighboring gene centrosomal protein 135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56915160-56915835 Neighboring gene VISTA enhancer hs1651 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56952044-56952696 Neighboring gene RNA, 5S ribosomal pseudogene 161 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:57092588-57093151 Neighboring gene uncharacterized LOC101928760 Neighboring gene RNA, U6 small nuclear 197, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:57176503-57177702 Neighboring gene uncharacterized LOC124900707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:57179040-57179540 Neighboring gene mitochondrial ribosomal protein L22 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 162 Neighboring gene ribosomal protein L7a pseudogene 31 Neighboring gene aminoadipate-semialdehyde dehydrogenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564H1363

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    capping protein-inhibiting regulator of actin dynamics
    Names
    cancer-related regulator of actin dynamics

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393381.1NP_001380310.1  capping protein-inhibiting regulator of actin dynamics isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620, AC092627
      Consensus CDS
      CCDS43230.1
      UniProtKB/Swiss-Prot
      Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
      UniProtKB/TrEMBL
      B7ZMH1
      Related
      ENSP00000507165.1, ENST00000682029.1
      Conserved Domains (4) summary
      PTZ00121
      Location:219526
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:6231060
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:9341217
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:45172
      DUF4592; Domain of unknown function (DUF4592)
    2. NM_001393382.1NP_001380311.1  capping protein-inhibiting regulator of actin dynamics isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620
      Consensus CDS
      CCDS43230.1
      UniProtKB/Swiss-Prot
      Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
      UniProtKB/TrEMBL
      B7ZMH1
      Related
      ENSP00000423366.1, ENST00000504228.6
      Conserved Domains (4) summary
      PTZ00121
      Location:219526
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:6231060
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:9341217
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:45172
      DUF4592; Domain of unknown function (DUF4592)
    3. NM_001393383.1NP_001380312.1  capping protein-inhibiting regulator of actin dynamics isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620, AC092627
      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:161468
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:5651002
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8761159
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:3114
      DUF4592; Domain of unknown function (DUF4592)
    4. NM_001393384.1NP_001380313.1  capping protein-inhibiting regulator of actin dynamics isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620, AC092627
      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:161468
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:5651002
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8761159
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:3114
      DUF4592; Domain of unknown function (DUF4592)
    5. NM_001393385.1NP_001380314.1  capping protein-inhibiting regulator of actin dynamics isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620
      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:161468
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:5651002
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8761159
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:3114
      DUF4592; Domain of unknown function (DUF4592)
    6. NM_020722.2NP_065773.1  capping protein-inhibiting regulator of actin dynamics isoform 1

      See identical proteins and their annotated locations for NP_065773.1

      Status: VALIDATED

      Source sequence(s)
      AC022267, AC068620
      Consensus CDS
      CCDS43230.1
      UniProtKB/Swiss-Prot
      Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
      UniProtKB/TrEMBL
      B7ZMH1
      Related
      ENSP00000264229.6, ENST00000264229.11
      Conserved Domains (4) summary
      PTZ00121
      Location:219526
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:6231060
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:9341217
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:45172
      DUF4592; Domain of unknown function (DUF4592)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      56049098..56330609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047415994.1XP_047271950.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6P1, B7ZMH1
    2. XM_047415995.1XP_047271951.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y6P1, B7ZMH1
      Related
      ENSP00000495373.2, ENST00000646253.2
    3. XM_005265752.3XP_005265809.1  capping protein-inhibiting regulator of actin dynamics isoform X2

      See identical proteins and their annotated locations for XP_005265809.1

      UniProtKB/Swiss-Prot
      Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:219526
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:6231060
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:9341217
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:45172
      DUF4592; Domain of unknown function (DUF4592)
    4. XM_017008473.2XP_016863962.2  capping protein-inhibiting regulator of actin dynamics isoform X3

      UniProtKB/TrEMBL
      B7ZVZ4, F5H1N7
      Related
      ENSP00000444006.1, ENST00000541073.5
    5. XM_005265756.3XP_005265813.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:129436
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:533970
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8441127
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:282
      DUF4592; Domain of unknown function (DUF4592)
    6. XM_005265755.3XP_005265812.1  capping protein-inhibiting regulator of actin dynamics isoform X4

      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:137444
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:541978
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8521135
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:1390
      DUF4592; Domain of unknown function (DUF4592)
    7. XM_006714045.3XP_006714108.1  capping protein-inhibiting regulator of actin dynamics isoform X6

      UniProtKB/TrEMBL
      B7ZMH1
      Conserved Domains (4) summary
      PTZ00121
      Location:105412
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:509946
      PHA03247; large tegument protein UL36; Provisional
      PRK10811
      Location:8201103
      rne; ribonuclease E; Reviewed
      pfam15262
      Location:558
      DUF4592; Domain of unknown function (DUF4592)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      59537287..59818577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350561.1XP_054206536.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      UniProtKB/TrEMBL
      B7ZMH1
    2. XM_054350560.1XP_054206535.1  capping protein-inhibiting regulator of actin dynamics isoform X1

      UniProtKB/TrEMBL
      B7ZMH1
    3. XM_054350562.1XP_054206537.1  capping protein-inhibiting regulator of actin dynamics isoform X2

      UniProtKB/TrEMBL
      B7ZMH1
    4. XM_054350563.1XP_054206538.1  capping protein-inhibiting regulator of actin dynamics isoform X3

      UniProtKB/TrEMBL
      B2RWN6
    5. XM_054350565.1XP_054206540.1  capping protein-inhibiting regulator of actin dynamics isoform X5

      UniProtKB/TrEMBL
      B7ZMH1
    6. XM_054350564.1XP_054206539.1  capping protein-inhibiting regulator of actin dynamics isoform X4

      UniProtKB/TrEMBL
      B7ZMH1
    7. XM_054350566.1XP_054206541.1  capping protein-inhibiting regulator of actin dynamics isoform X6

      UniProtKB/TrEMBL
      B7ZMH1