Mvd mevalonate diphosphate decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mvdprovided by RGD
Official Full Name: mevalonate diphosphate decarboxylaseprovided by RGD
Primary source: RGD:621292
See related: EnsemblRapid:ENSRNOG00000013376 AllianceGenome:RGD:621292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mvpd
Summary: Enables diphosphomevalonate decarboxylase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and response to xenobiotic stimulus. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 70.0), Liver (RPKM 64.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67404911..67414974, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50496366..50506429, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55258910..55268933, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the upregulation of miR-214 and downregulation of MPD transcription in the liver both play a role in the development of hypocholesterolemia
Title: Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers.
Distribution of mevalonate pyrophosphate decarboxylase is significantly reduced in the liver as well as brain of the stroke-prone spontaneously hypertensive rat from the age of two weeks, compared to that of the normotensive Wistar Kyoto strain.
Title: Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks.
The 45-kDa isoform of mevalonate pyrophosphate decarboxylase has been detected in the matrix of the liver peroxisomes, whereas the 37-kDa form localizes primarily to the liver cytosol.
Title: Difference in subcellular distribution between 45- and 37-kDa mevalonate pyrophosphate decarboxylase in rat liver.

Submit: New GeneRIF Correction

General gene information

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Markers

Mvd (e-PCR), detects polymorphism
- UniSTS:546875

RH131095 (e-PCR)
- UniSTS:214378

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables diphosphomevalonate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphomevalonate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphomevalonate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables diphosphomevalonate decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables diphosphomevalonate decarboxylase activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
NOT located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diphosphomevalonate decarboxylase

Names: MDDase; mevalonate (diphospho) decarboxylase; mevalonate pyrophosphate decarboxylase

NP_112324.2

EC 4.1.1.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031062.3 → NP_112324.2 diphosphomevalonate decarboxylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q62967, Q642E5

UniProtKB/TrEMBL

A0A8I6G6D2

Related

ENSRNOP00000080265.2, ENSRNOT00000106812.2

Conserved Domains (1) summary

cl28577
Location:9 → 338

MVD1; Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]