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    Krt5 keratin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 369017, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt5provided by RGD
    Official Full Name
    keratin 5provided by RGD
    Primary source
    RGD:727894
    See related
    EnsemblRapid:ENSRNOG00000050420 AllianceGenome:RGD:727894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    K5; CK-5; Sak57; Krt2-5
    Summary
    Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament cytoskeleton organization; keratinization; and response to mechanical stimulus. Located in keratin filament. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 457.0) See more
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    Genomic context

    See Krt5 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134724840..134730569, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132846132..132851861, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143320142..143324536, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin, type II cytoskeletal 6A-like Neighboring gene keratin 6A Neighboring gene keratin 71 Neighboring gene keratin 72

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intermediate filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intermediate filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 5
    Names
    cytokeratin-5
    keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)
    keratin 5, type II
    keratin 8
    keratin complex 2, basic, gene 5
    type-II keratin Kb5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183333.2NP_899162.2  keratin, type II cytoskeletal 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q6P6Q2, Q7TN97
      UniProtKB/TrEMBL
      A6KCR1
      Related
      ENSRNOP00000011644.6, ENSRNOT00000011644.7
      Conserved Domains (2) summary
      pfam00038
      Location:163476
      Filament; Intermediate filament protein
      pfam16208
      Location:16160
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134724840..134730569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)