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    Snrpb2 small nuclear ribonucleoprotein polypeptide B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362223, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snrpb2provided by RGD
    Official Full Name
    small nuclear ribonucleoprotein polypeptide B2provided by RGD
    Primary source
    RGD:1310194
    See related
    EnsemblRapid:ENSRNOG00000004967 AllianceGenome:RGD:1310194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of small nuclear ribonucleoprotein complex. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 253.3), Spleen (RPKM 170.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrpb2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (150852814..150862364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (130399239..130408821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (137138082..137147575)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 16B Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120101719 Neighboring gene otoraplin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Habets WJ, et al. Proc Natl Acad Sci U S A, 1987 Apr. PMID 2951739, Free PMC Article
    2. A novel 40S multi-snRNP complex isolated from rat liver nuclei. Guialis A, et al. Nucleic Acids Res, 1991 Jan 25. PMID 1707521, Free PMC Article
    3. Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer. Rozanov DV, et al. Cancer Res, 2008 Jun 1. PMID 18519667, Free PMC Article
    4. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. Craft J, et al. J Clin Invest, 1988 Jun. PMID 2968364, Free PMC Article
    5. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. Neubauer G, et al. Nat Genet, 1998 Sep. PMID 9731529

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small nuclear ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear ribonucleoprotein B''
    Names
    U2 small nuclear ribonucleoprotein B
    small nuclear ribonucleoprotein polypeptide B''

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108592.3 → NP_001102062.1  U2 small nuclear ribonucleoprotein B''

      See identical proteins and their annotated locations for NP_001102062.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GAM2, B5DEQ4, F7EX25
      Conserved Domains (2) summary
      cd12481
      Location:146 → 225
      RRM2_U2B; RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
      cd12478
      Location:6 → 96
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      150852814..150862364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105469.2 → XP_038961397.1  U2 small nuclear ribonucleoprotein B'' isoform X1

      UniProtKB/TrEMBL
      A0A8I6GAM2
      Related
      ENSRNOP00000100537.1, ENSRNOT00000172496.1
      Conserved Domains (2) summary
      cd12481
      Location:164 → 243
      RRM2_U2B; RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
      cd12478
      Location:24 → 114
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins

    2. XM_039105470.2 → XP_038961398.1  U2 small nuclear ribonucleoprotein B'' isoform X2

      UniProtKB/TrEMBL
      A0A8I6GAM2, B5DEQ4, F7EX25
      Related
      ENSRNOP00000006900.4, ENSRNOT00000006900.9
      Conserved Domains (2) summary
      cd12481
      Location:146 → 225
      RRM2_U2B; RNA recognition motif 2 (RRM2) found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")
      cd12478
      Location:6 → 96
      RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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