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    Gba3 glucosylceramidase beta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289687, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gba3provided by RGD
    Official Full Name
    glucosylceramidase beta 3provided by RGD
    Primary source
    RGD:1309539
    See related
    EnsemblRapid:ENSRNOG00000024634 AllianceGenome:RGD:1309539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in several processes, including glycosylceramide catabolic process; positive regulation of exo-alpha-sialidase activity; and protein stabilization. Predicted to be part of catalytic complex. Predicted to be active in cytosol. Orthologous to human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 660.0) See more
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    Genomic context

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    See Gba3 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (64787601..64934043, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (60574974..60721411, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (64390793..64535213, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene rabenosyn, RAB effector, pseudogene 1 Neighboring gene cytochrome c, somatic, pseudogene 3 Neighboring gene uncharacterized LOC134481906 Neighboring gene adhesion G protein-coupled receptor A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation. Dekker N, et al. Blood Cells Mol Dis, 2011 Jan 15. PMID 20728381
    2. Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. Hayashi Y, et al. J Biol Chem, 2007 Oct 19. PMID 17595169
    3. Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. Berrin JG, et al. Eur J Biochem, 2002 Jan. PMID 11784319
    4. Cloning and characterization of human liver cytosolic beta-glycosidase. de Graaf M, et al. Biochem J, 2001 Jun 15. PMID 11389701, Free PMC Article
    5. GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription. Li J, et al. Aging (Albany NY), 2024 Feb 29. PMID 38428407, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
      Title: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosylceramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucosylceramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosylceramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in beta-glucoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in galactosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in glucosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucosylceramide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exo-alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucosylceramidase beta 3
    Names
    cytosolic beta-glucosidase
    glucosidase, beta, acid 3 (cytosolic)
    NP_001382556.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395627.1 → NP_001382556.1  glucosylceramidase beta 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JVP8, G3V8Y1
      Related
      ENSRNOP00000069571.2, ENSRNOT00000082338.3
      Conserved Domains (1) summary
      cl23725
      Location:4 → 456
      Glyco_hydro; Glycosyl hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      64787601..64934043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106010.1: Suppressed sequence

      Description
      NM_001106010.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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