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    ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 9475, updated on 27-Dec-2024

    Summary

    Official Symbol
    ROCK2provided by HGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:10252
    See related
    Ensembl:ENSG00000134318 MIM:604002; AllianceGenome:HGNC:10252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROCK-II
    Summary
    The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ROCK2 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (11179759..11345437, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (11212159..11378745, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11319885..11485563, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11292424-11292924 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11171 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:11298670-11298918 Neighboring gene solute carrier family 66 member 3 Neighboring gene Sharpr-MPRA regulatory region 13580 Neighboring gene RNA, U6 small nuclear 1081, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11397407-11397926 Neighboring gene AIDA pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11174 Neighboring gene uncharacterized LOC124907733 Neighboring gene Sharpr-MPRA regulatory region 7779 Neighboring gene peptidylprolyl isomerase A pseudogene 60

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
    matrix gag HIV-1 p17-mediated activation of the Rho/ROCK-signaling pathway is required for p17-mediated monocyte adhesion and migration PubMed
    gag HIV-1 p17-induced activation of PTEN is regulated by RhoA-associated kinase (ROCK) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0619

    Gene Ontology Provided by GOA

    Items 1 - 25 of 36
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables RNA binding PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity PubMed 
    enables Rho-dependent protein serine/threonine kinase activity PubMed 
    enables endopeptidase activator activity PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protease binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding  
    enables structural molecule activity PubMed 
    enables tau protein binding PubMed 
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 36
    Items 1 - 25 of 62
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction PubMed 
    involved_in actin cytoskeleton organization  
    involved_in actomyosin structure organization  
    involved_in aortic valve morphogenesis  
    involved_in blood vessel diameter maintenance  
    involved_in cellular response to acetylcholine  
    involved_in cellular response to testosterone stimulus PubMed 
    involved_in centrosome duplication PubMed 
    involved_in chromatin remodeling  
    involved_in cortical actin cytoskeleton organization  
    involved_in embryonic morphogenesis  
    involved_in epithelial to mesenchymal transition  
    involved_in mRNA destabilization  
    involved_in mitotic cytokinesis  
    involved_in modulation by host of viral process PubMed 
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of bicellular tight junction assembly PubMed 
    involved_in negative regulation of biomineral tissue development  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of nitric oxide biosynthetic process PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process  
    involved_in negative regulation of protein localization to lysosome PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of amyloid precursor protein catabolic process PubMed 
    involved_in positive regulation of amyloid-beta formation PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of centrosome duplication  
    involved_in positive regulation of connective tissue growth factor production  
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of fibroblast growth factor production  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of protein localization to early endosome PubMed 
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of cell adhesion PubMed 
    involved_in regulation of cell junction assembly  
    involved_in regulation of cell motility PubMed 
    involved_in regulation of cellular response to hypoxia  
    involved_in regulation of circadian rhythm  
    involved_in regulation of establishment of cell polarity PubMed 
    involved_in regulation of establishment of endothelial barrier PubMed 
    involved_in regulation of establishment of endothelial barrier PubMed 
    involved_in regulation of focal adhesion assembly PubMed 
    involved_in regulation of keratinocyte differentiation PubMed 
    involved_in regulation of nervous system process  
    involved_in regulation of stress fiber assembly PubMed 
    involved_in response to angiotensin  
    involved_in response to ischemia  
    involved_in response to transforming growth factor beta  
    involved_in rhythmic process  
    involved_in smooth muscle contraction PubMed 
    Items 1 - 25 of 62
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome PubMed 
    is_active_in cytoplasm  
    is_active_in cytoplasm PubMed 
    located_in cytoplasmic ribonucleoprotein granule PubMed 
    is_active_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    rho-associated protein kinase 2
    Names
    p164 ROCK-2
    rho-associated, coiled-coil-containing protein kinase II
    NP_001308572.1
    NP_004841.2
    XP_005246247.1
    XP_011508719.1
    XP_016860867.1
    XP_016860868.1
    XP_054200614.1
    XP_054200615.1
    XP_054200616.1
    XP_054200617.1
    XP_054200618.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029769.1 RefSeqGene

      Range
      4950..169827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321643.2 → NP_001308572.1  rho-associated protein kinase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB014519, AC018463, AC099344, AL049383, BC111801
      UniProtKB/TrEMBL
      A0A8V8TL82
      Related
      ENSP00000385509.1, ENST00000401753.5
      Conserved Domains (7) summary
      cd11638
      Location:419 → 485
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:6 → 268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:350 → 1015
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1175 → 1221
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1065 → 1171
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05596
      Location:1 → 330
      STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
      pfam08912
      Location:893 → 960
      Rho_Binding; Rho Binding
    2. NM_004850.5 → NP_004841.2  rho-associated protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_004841.2

      Status: REVIEWED

      Source sequence(s)
      AB014519, AC018463, AC099344, AL049383, BC111801
      Consensus CDS
      CCDS42654.1
      UniProtKB/Swiss-Prot
      O75116, Q53QZ0, Q53SJ7, Q9UQN5
      UniProtKB/TrEMBL
      A0A2P9DU05, A0A8V8TL82
      Related
      ENSP00000317985.6, ENST00000315872.11
      Conserved Domains (5) summary
      cd11638
      Location:505 → 571
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      cd00029
      Location:1261 → 1307
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1151 → 1257
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05621
      Location:39 → 417
      STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
      cl25732
      Location:436 → 1101
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      11179759..11345437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510417.3 → XP_011508719.1  rho-associated protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TL82
      Conserved Domains (7) summary
      cd11638
      Location:419 → 485
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:6 → 268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:350 → 1015
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1175 → 1221
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1065 → 1171
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05596
      Location:1 → 330
      STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
      pfam08912
      Location:893 → 960
      Rho_Binding; Rho Binding
    2. XM_005246190.4 → XP_005246247.1  rho-associated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TL82
      Conserved Domains (7) summary
      pfam05483
      Location:412 → 1080
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd11638
      Location:505 → 571
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:92 → 354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1261 → 1307
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1151 → 1257
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05621
      Location:39 → 417
      STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
      pfam08912
      Location:979 → 1046
      Rho_Binding; Rho Binding
    3. XM_017005379.3 → XP_016860868.1  rho-associated protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TL82
      Conserved Domains (7) summary
      cd11638
      Location:419 → 485
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:6 → 268
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:350 → 1015
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1175 → 1221
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1065 → 1171
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05596
      Location:1 → 330
      STKc_ROCK; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
      pfam08912
      Location:893 → 960
      Rho_Binding; Rho Binding
    4. XM_017005378.3 → XP_016860867.1  rho-associated protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL82

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      11212159..11378745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344641.1 → XP_054200616.1  rho-associated protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TL82
    2. XM_054344639.1 → XP_054200614.1  rho-associated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V8TL82
    3. XM_054344643.1 → XP_054200618.1  rho-associated protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TL82
    4. XM_054344642.1 → XP_054200617.1  rho-associated protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      E9PF63
    5. XM_054344640.1 → XP_054200615.1  rho-associated protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TL82
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