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    IGFL4 IGF like family member 4 [ Homo sapiens (human) ]

    Gene ID: 444882, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IGFL4provided by HGNC
    Official Full Name
    IGF like family member 4provided by HGNC
    Primary source
    HGNC:HGNC:32931
    See related
    Ensembl:ENSG00000204869 MIM:610547; AllianceGenome:HGNC:32931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in skin (RPKM 2.1), brain (RPKM 0.4) and 1 other tissue See more
    Orthologs
    all
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    Genomic context

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    See IGFL4 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46039182..46077629, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48866645..48905083, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46542440..46580887, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46524919-46525804 Neighboring gene uncharacterized LOC105372421 Neighboring gene peptidoglycan recognition protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46535831-46536434 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene IGF like family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. Emtage P, et al. Genomics, 2006 Oct. PMID 16890402
    2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ39303

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulin growth factor-like family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002923.3 → NP_001002923.1  insulin growth factor-like family member 4 precursor

      See identical proteins and their annotated locations for NP_001002923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC007785
      Consensus CDS
      CCDS33057.1
      UniProtKB/Swiss-Prot
      Q6B9Z1
      Related
      ENSP00000366926.1, ENST00000377697.2
      Conserved Domains (1) summary
      pfam14653
      Location:20 → 108
      IGFL; Insulin growth factor-like family

    RNA

    1. NR_163175.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007785

    2. NR_163176.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007785

    3. NR_163177.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007785

    4. NR_169756.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007785

    5. NR_169757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007785

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46039182..46077629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438851.1 → XP_047294807.1  insulin growth factor-like family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6B9Z1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48866645..48905083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321053.1 → XP_054177028.1  insulin growth factor-like family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6B9Z1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_125344.1: Suppressed sequence

      Description
      NR_125344.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6B9Z1.1 GenPept UniProtKB/Swiss-Prot:Q6B9Z1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials