GAGE2C G antigen 2C [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAGE2Cprovided by HGNC
Official Full Name: G antigen 2Cprovided by HGNC
Primary source: HGNC:HGNC:31958
See related: MIM:300595; AllianceGenome:HGNC:31958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT4.2; GAGE2; GAGE-2; GAGE-2C
Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]
Annotation information: not in current annotation release
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Genomic context

Location:: Xp11.23

Annotation release	Status	Assembly	Chr	Location
RS_2024_09	latest, but not current	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (49226171..49233491)

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that EZH2 is a crucial regulator of GAGE2 expression.
Title: Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.

Submit: New GeneRIF Correction

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485400

NoName (e-PCR)
- UniSTS:481091

NoName (e-PCR)
- UniSTS:481101

NoName (e-PCR)
- UniSTS:482134

NoName (e-PCR)
- UniSTS:487065

NoName (e-PCR)
- UniSTS:480440

NoName (e-PCR)
- UniSTS:494525

NoName (e-PCR)
- UniSTS:489699

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: G antigen 2B/2C

Names: G antigen 2; cancer/testis antigen 4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.