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    MIER3 MIER family member 3 [ Homo sapiens (human) ]

    Gene ID: 166968, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MIER3provided by HGNC
    Official Full Name
    MIER family member 3provided by HGNC
    Primary source
    HGNC:HGNC:26678
    See related
    Ensembl:ENSG00000155545 MIM:620100; AllianceGenome:HGNC:26678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of protein-containing complex. Implicated in breast cancer and lung adenocarcinoma. Biomarker of breast cancer; invasive ductal carcinoma; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon (RPKM 18.3), duodenum (RPKM 12.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIER3 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (56919603..56952209, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (57747855..57780385, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (56215430..56247950, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 1 Neighboring gene uncharacterized LOC124901214 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86223 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:56178189-56179388 Neighboring gene uncharacterized LOC105378980 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:56206084-56206905 Neighboring gene SET domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16028 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86248 Neighboring gene small nuclear ribonucleoprotein polypeptide B2 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86269 Neighboring gene Sharpr-MPRA regulatory region 15622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22576 Neighboring gene uncharacterized LOC124900981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16029 Neighboring gene Sharpr-MPRA regulatory region 9364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition. Peng M, et al. Sci Rep, 2017 Sep 8. PMID 28887525, Free PMC Article
    2. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. Huang W, et al. Exp Cell Res, 2021 Sep 1. PMID 34242623
    3. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
    4. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
    5. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Bantscheff M, et al. Nat Biotechnol, 2011 Mar. PMID 21258344

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
      Title: MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
    2. our data suggested that MIER3 plays a potential tumor suppressor role in CRC progression and may be a potentially valuable clinical prognostic marker of this disease.
      Title: MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition.
    3. Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity.
      Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
    4. Data suggest that the human 5q11.2 breast cancer risk allele marked by rs889312 is mammary gland autonomous, and MIER3 is a candidate breast cancer susceptibility gene.
      Title: Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35954, DKFZp781G1119, DKFZp781I1119, DKFZp686L09111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mesoderm induction early response protein 3
    Names
    mesoderm induction early response 1, family member 3
    mi-er3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297598.2 → NP_001284527.1  mesoderm induction early response protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001284527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008937, AC016644
      Consensus CDS
      CCDS78011.1
      UniProtKB/Swiss-Prot
      Q7Z3K6
      Related
      ENSP00000370624.3, ENST00000381226.7
      Conserved Domains (3) summary
      smart00717
      Location:285 → 332
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:287 → 331
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:181 → 229
      ELM2; ELM2 domain

    2. NM_001297599.2 → NP_001284528.1  mesoderm induction early response protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001284528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC008937, AC016644
      Consensus CDS
      CCDS75248.1
      UniProtKB/Swiss-Prot
      B4DRI9, B8ZZQ0, Q5CZI0, Q68CS3, Q6MZS7, Q7Z3K6, Q86YG8, Q8NA13
      Related
      ENSP00000370596.3, ENST00000381199.8
      Conserved Domains (2) summary
      cd11661
      Location:282 → 326
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176 → 224
      ELM2; ELM2 domain

    3. NM_152622.5 → NP_689835.3  mesoderm induction early response protein 3 isoform 3

      See identical proteins and their annotated locations for NP_689835.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has two alternate splice sites in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and an internal aa, compared to isoform 1.
      Source sequence(s)
      AC008937, AC016644
      Consensus CDS
      CCDS3973.2
      UniProtKB/Swiss-Prot
      Q7Z3K6
      Related
      ENSP00000370611.3, ENST00000381213.7
      Conserved Domains (2) summary
      cd11661
      Location:281 → 325
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176 → 224
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      56919603..56952209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416840.1 → XP_047272796.1  mesoderm induction early response protein 3 isoform X3

    2. XM_011543217.3 → XP_011541519.1  mesoderm induction early response protein 3 isoform X2

      Conserved Domains (3) summary
      smart00717
      Location:295 → 342
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:297 → 341
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:192 → 240
      ELM2; ELM2 domain

    3. XM_011543216.3 → XP_011541518.1  mesoderm induction early response protein 3 isoform X1

      Conserved Domains (2) summary
      cd11661
      Location:298 → 342
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:192 → 240
      ELM2; ELM2 domain

    4. XM_047416839.1 → XP_047272795.1  mesoderm induction early response protein 3 isoform X3

      Related
      ENSP00000386584.1, ENST00000409421.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      57747855..57780385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351878.1 → XP_054207853.1  mesoderm induction early response protein 3 isoform X2

    2. XM_054351877.1 → XP_054207852.1  mesoderm induction early response protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z3K6.2 GenPept UniProtKB/Swiss-Prot:Q7Z3K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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