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    CDK17 cyclin dependent kinase 17 [ Homo sapiens (human) ]

    Gene ID: 5128, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CDK17provided by HGNC
    Official Full Name
    cyclin dependent kinase 17provided by HGNC
    Primary source
    HGNC:HGNC:8750
    See related
    Ensembl:ENSG00000059758 MIM:603440; AllianceGenome:HGNC:8750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCTK2; PCTAIRE2
    Summary
    The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK17 in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (96278225..96400439, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (96252431..96374639, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96672003..96794217, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6189 Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96603880-96604402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6826 Neighboring gene uncharacterized LOC124902991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96628784-96629768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96631810-96632310 Neighboring gene ETS transcription factor ELK3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709352-96709984 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709985-96710615 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6830 Neighboring gene RN7SK pseudogene 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:96878154-96878351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6832 Neighboring gene Sharpr-MPRA regulatory region 2123 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:96894427-96895626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4746 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:96915910-96916410 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:96916411-96916911 Neighboring gene cilia and flagella associated protein 54 Neighboring gene MPRA-validated peak1903 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97122708-97123302

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology. Chaput D, et al. Oncotarget, 2016 Feb 23. PMID 26885753, Free PMC Article
    2. CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression. Qu B, et al. Carcinogenesis, 2024 Feb 12. PMID 37952105
    3. CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer. Chen R, et al. J Ovarian Res, 2022 Feb 15. PMID 35168653, Free PMC Article
    4. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. Hirose T, et al. Eur J Biochem, 1997 Oct 15. PMID 9370357
    5. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Hirose T, et al. Eur J Biochem, 2000 Apr. PMID 10727952

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
      Title: CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.
    2. CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
      Title: CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.
    3. Increased levels of PCTAIRE2 is associated with Alzheimer's disease.
      Title: Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 17
    Names
    PCTAIRE-motif protein kinase 2
    cell division protein kinase 17
    protein kinase cdc2-related PCTAIRE-2
    serine/threonine-protein kinase PCTAIRE-2
    NP_001163935.1
    NP_002586.2
    XP_016874894.1
    XP_016874895.1
    XP_016874896.1
    XP_054228168.1
    XP_054228169.1
    XP_054228170.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170464.4 → NP_001163935.1  cyclin-dependent kinase 17 isoform 2

      See identical proteins and their annotated locations for NP_001163935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.
      Source sequence(s)
      AC008149, AC125612, AF086067, AK290011, BC033005, DA530711
      Consensus CDS
      CCDS53819.1
      UniProtKB/TrEMBL
      B4DGP5
      Related
      ENSP00000444459.2, ENST00000543119.6
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    2. NM_002595.5 → NP_002586.2  cyclin-dependent kinase 17 isoform 1

      See identical proteins and their annotated locations for NP_002586.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AF086067, BC033005, DC307775
      Consensus CDS
      CCDS9061.1
      UniProtKB/Swiss-Prot
      A8K1U6, B2RCQ2, Q00537, Q8NEB8
      UniProtKB/TrEMBL
      B4DGP5
      Related
      ENSP00000261211.3, ENST00000261211.8
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      96278225..96400439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019407.3 → XP_016874896.1  cyclin-dependent kinase 17 isoform X2

      UniProtKB/TrEMBL
      B4DGP5

    2. XM_017019406.2 → XP_016874895.1  cyclin-dependent kinase 17 isoform X1

      UniProtKB/Swiss-Prot
      A8K1U6, B2RCQ2, Q00537, Q8NEB8
      UniProtKB/TrEMBL
      B4DGP5
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    3. XM_017019405.2 → XP_016874894.1  cyclin-dependent kinase 17 isoform X1

      UniProtKB/Swiss-Prot
      A8K1U6, B2RCQ2, Q00537, Q8NEB8
      UniProtKB/TrEMBL
      B4DGP5
      Conserved Domains (1) summary
      cd07872
      Location:185 → 493
      STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      96252431..96374639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372195.1 → XP_054228170.1  cyclin-dependent kinase 17 isoform X2

      UniProtKB/TrEMBL
      B4DGP5

    2. XM_054372194.1 → XP_054228169.1  cyclin-dependent kinase 17 isoform X1

      UniProtKB/Swiss-Prot
      A8K1U6, B2RCQ2, Q00537, Q8NEB8
      UniProtKB/TrEMBL
      B4DGP5

    3. XM_054372193.1 → XP_054228168.1  cyclin-dependent kinase 17 isoform X1

      UniProtKB/Swiss-Prot
      A8K1U6, B2RCQ2, Q00537, Q8NEB8
      UniProtKB/TrEMBL
      B4DGP5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00537.2 GenPept UniProtKB/Swiss-Prot:Q00537

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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