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    FABP1 fatty acid binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 2168, updated on 27-Dec-2024

    Summary

    Official Symbol
    FABP1provided by HGNC
    Official Full Name
    fatty acid binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:3555
    See related
    Ensembl:ENSG00000163586 MIM:134650; AllianceGenome:HGNC:3555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FABPL; L-FABP
    Summary
    This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
    Expression
    Biased expression in liver (RPKM 2613.3), colon (RPKM 1932.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FABP1 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (88122982..88128062, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (88134227..88181784, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88422501..88427581, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene lysine rich coiled-coil 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16167 Neighboring gene CRISPRi-validated cis-regulatory element chr2.3248 Neighboring gene skeletal muscle cis-regulatory module upstream of SMYD1 Neighboring gene Sharpr-MPRA regulatory region 1533 Neighboring gene SET and MYND domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11728 Neighboring gene microRNA 4780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:88406623-88407124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:88407125-88407624 Neighboring gene Sharpr-MPRA regulatory region 11659 Neighboring gene uncharacterized LOC101928347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:88485325-88486142 Neighboring gene threonine synthase like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of fatty acid binding protein 1, liver (FABP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bile acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heterocyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fatty acid-binding protein, liver
    Names
    fatty acid binding protein 1, liver
    liver-type fatty acid-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001443.3NP_001434.1  fatty acid-binding protein, liver

      See identical proteins and their annotated locations for NP_001434.1

      Status: REVIEWED

      Source sequence(s)
      BC022287, BP263155, M10617
      Consensus CDS
      CCDS2001.1
      UniProtKB/Swiss-Prot
      P07148
      UniProtKB/TrEMBL
      Q05CP7, Q6FGL7
      Related
      ENSP00000295834.3, ENST00000295834.8
      Conserved Domains (1) summary
      cl21528
      Location:3127
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      88122982..88128062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      88134227..88181784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341028.1XP_054197003.1  fatty acid-binding protein, liver isoform X1

      UniProtKB/TrEMBL
      Q05CP7