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    ZNF433 zinc finger protein 433 [ Homo sapiens (human) ]

    Gene ID: 163059, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF433provided by HGNC
    Official Full Name
    zinc finger protein 433provided by HGNC
    Primary source
    HGNC:HGNC:20811
    See related
    Ensembl:ENSG00000197647 AllianceGenome:HGNC:20811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 9.0), thyroid (RPKM 2.5) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF433 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12014715..12035679, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12142922..12163886, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12125530..12146494, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene zinc finger protein 763 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12098284-12099226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12099227-12100168 Neighboring gene ZNF433 and ZNF878 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10139 Neighboring gene RNA, 5S ribosomal pseudogene 465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12163610-12164115 Neighboring gene zinc finger protein 878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10141 Neighboring gene RNA, 5S ribosomal pseudogene 466 Neighboring gene zinc finger protein 844

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma. Heyliger SO, et al. Biomolecules, 2021 Aug 12. PMID 34439859, Free PMC Article
    2. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Nischwitz S, et al. J Neuroimmunol, 2010 Oct 8. PMID 20598377
    3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma.
      Title: The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma.
    2. ZNF433 has been identified as a candidate gene in a genome-wide association study of German multiple sclerosis patients.
      Title: Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40981

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 433

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080411.3 → NP_001073880.1  zinc finger protein 433 isoform 1

      See identical proteins and their annotated locations for NP_001073880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest isoform (1).
      Source sequence(s)
      AC008770, AK098300, DB515835
      Consensus CDS
      CCDS45983.1
      UniProtKB/Swiss-Prot
      Q86VX3, Q8N7K0
      Related
      ENSP00000339767.6, ENST00000344980.11
      Conserved Domains (5) summary
      smart00349
      Location:7 → 49
      KRAB; krueppel associated box
      COG5048
      Location:197 → 603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:228 → 248
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 46
      KRAB; KRAB box
      pfam13465
      Location:240 → 265
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001308346.2 → NP_001295275.1  zinc finger protein 433 isoform 2

      See identical proteins and their annotated locations for NP_001295275.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC008770, BC047412, DB454511, DB515835
      Consensus CDS
      CCDS92523.1
      UniProtKB/TrEMBL
      F8W0C9
      Related
      ENSP00000447205.2, ENST00000550745.3
      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:196 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:239 → 264
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001308348.2 → NP_001295277.1  zinc finger protein 433 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC008770, BC047412, CN345816, DA452530, DB515835
      Consensus CDS
      CCDS92525.1
      UniProtKB/TrEMBL
      F8VTV7
      Related
      ENSP00000448099.2, ENST00000550507.7
      Conserved Domains (4) summary
      COG5048
      Location:194 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box
      pfam13465
      Location:629 → 654
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001308351.2 → NP_001295280.1  zinc finger protein 433 isoform 4

      See identical proteins and their annotated locations for NP_001295280.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses two alternate exons and an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus than isoform 1. Variants 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC008770, BC047412, BI831553, DB515835
      Consensus CDS
      CCDS77240.1
      Conserved Domains (2) summary
      COG5048
      Location:162 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001308355.2 → NP_001295284.1  zinc finger protein 433 isoform 4

      See identical proteins and their annotated locations for NP_001295284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate exon and alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1. Variants 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC008770, BC047412, DA452530, DB450226, DB515835
      Consensus CDS
      CCDS77240.1
      Related
      ENSP00000448806.2, ENST00000547560.6
      Conserved Domains (2) summary
      COG5048
      Location:162 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001308357.2 → NP_001295286.1  zinc finger protein 433 isoform 4

      See identical proteins and their annotated locations for NP_001295286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate exon and alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1. Variants 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC008770, BC047412, DA452530, DB515835
      Consensus CDS
      CCDS77240.1
      Related
      ENSP00000393416.2, ENST00000419886.7
      Conserved Domains (2) summary
      COG5048
      Location:162 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12014715..12035679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527725.3 → XP_011526027.1  zinc finger protein 433 isoform X2

      See identical proteins and their annotated locations for XP_011526027.1

      UniProtKB/TrEMBL
      C9JQA6, F8VU36
      Related
      ENSP00000447951.2, ENST00000478765.6
      Conserved Domains (5) summary
      smart00349
      Location:18 → 60
      KRAB; krueppel associated box
      COG5048
      Location:208 → 614
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:18 → 57
      KRAB; KRAB box
      pfam13465
      Location:251 → 276
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011527729.3 → XP_011526031.1  zinc finger protein 433 isoform X3

      See identical proteins and their annotated locations for XP_011526031.1

      UniProtKB/TrEMBL
      F8W0C9
      Related
      ENSP00000414857.3, ENST00000455504.7
      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:196 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:239 → 264
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011527728.3 → XP_011526030.1  zinc finger protein 433 isoform X3

      See identical proteins and their annotated locations for XP_011526030.1

      UniProtKB/TrEMBL
      F8W0C9
      Conserved Domains (5) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:196 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:239 → 264
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047438319.1 → XP_047294275.1  zinc finger protein 433 isoform X1

    5. XM_006722661.4 → XP_006722724.1  zinc finger protein 433 isoform X4

      See identical proteins and their annotated locations for XP_006722724.1

      Conserved Domains (2) summary
      COG5048
      Location:162 → 568
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12142922..12163886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320061.1 → XP_054176036.1  zinc finger protein 433 isoform X2

      UniProtKB/TrEMBL
      C9JQA6, F8VU36

    2. XM_054320063.1 → XP_054176038.1  zinc finger protein 433 isoform X3

      UniProtKB/TrEMBL
      F8W0C9

    3. XM_054320062.1 → XP_054176037.1  zinc finger protein 433 isoform X3

      UniProtKB/TrEMBL
      F8W0C9

    4. XM_054320060.1 → XP_054176035.1  zinc finger protein 433 isoform X1

    5. XM_054320064.1 → XP_054176039.1  zinc finger protein 433 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152602.1: Suppressed sequence

      Description
      NM_152602.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from laboratory mouse: 3000002G13Rik (GeneID:70227).
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7K0.1 GenPept UniProtKB/Swiss-Prot:Q8N7K0

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