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    DUSP3 dual specificity phosphatase 3 [ Homo sapiens (human) ]

    Gene ID: 1845, updated on 10-Dec-2024

    Summary

    Official Symbol
    DUSP3provided by HGNC
    Official Full Name
    dual specificity phosphatase 3provided by HGNC
    Primary source
    HGNC:HGNC:3069
    See related
    Ensembl:ENSG00000108861 MIM:600183; AllianceGenome:HGNC:3069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VHR
    Summary
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 57.5), esophagus (RPKM 29.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DUSP3 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43766125..43778977, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44618675..44631521, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41843493..41856345, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:41795928-41796532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8566 Neighboring gene Wolf-Hirschhorn syndrome candidate 1-like 2, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:41811531-41812180 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41821332-41821491 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41831689-41831891 Neighboring gene Sharpr-MPRA regulatory region 3915 Neighboring gene sclerostin Neighboring gene Sharpr-MPRA regulatory region 13819 Neighboring gene CFAP97 domain containing 1 Neighboring gene MAGUK p55 scaffold protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8568

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity  
    enables MAP kinase phosphatase activity PubMed 
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables cytoskeletal protein binding PubMed 
    enables histone H2AXS140 phosphatase activity  
    enables histone H2AXY142 phosphatase activity  
    enables myosin phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables phosphatase activity PubMed 
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein tyrosine kinase binding PubMed 
    enables protein tyrosine phosphatase activity PubMed 
    enables protein tyrosine phosphatase activity PubMed 
    enables protein tyrosine phosphatase activity  
    enables protein tyrosine phosphatase activity, metal-dependent  
    enables protein tyrosine/serine/threonine phosphatase activity  
    enables protein tyrosine/serine/threonine phosphatase activity PubMed 
    enables protein tyrosine/serine/threonine phosphatase activity PubMed 
    enables receptor tyrosine kinase binding PubMed 
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in chromatin remodeling  
    involved_in dephosphorylation PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of JNK cascade  
    involved_in negative regulation of JNK cascade PubMed 
    involved_in negative regulation of JNK cascade PubMed 
    involved_in negative regulation of MAPK cascade PubMed 
    involved_in negative regulation of T cell activation  
    involved_in negative regulation of T cell activation PubMed 
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in negative regulation of T cell receptor signaling pathway PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of chemotaxis PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in peptidyl-tyrosine dephosphorylation PubMed 
    involved_in peptidyl-tyrosine dephosphorylation PubMed 
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity PubMed 
    involved_in positive regulation of focal adhesion disassembly PubMed 
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of mitotic cell cycle PubMed 
    involved_in regulation of focal adhesion assembly PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoskeleton  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in immunological synapse PubMed 
    located_in motile cilium  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase 3
    Names
    dual specificity protein phosphatase VHR
    serine/threonine specific protein phosphatase
    vaccinia H1-related phosphatase
    vaccinia virus phosphatase VH1-related
    NP_004081.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004090.4NP_004081.1  dual specificity protein phosphatase 3

      See identical proteins and their annotated locations for NP_004081.1

      Status: REVIEWED

      Source sequence(s)
      AC055813, AK055834, AK129822, BC002682, BQ575811, BQ652984, DA075379, DA104250, DA167802, DB171573
      Consensus CDS
      CCDS11469.1
      UniProtKB/Swiss-Prot
      D3DX45, P51452, Q5U0J1, Q8IYJ9
      UniProtKB/TrEMBL
      B5BUI8
      Related
      ENSP00000226004.2, ENST00000226004.8
      Conserved Domains (1) summary
      cd14579
      Location:10177
      DUSP3; dual specificity protein phosphatase 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43766125..43778977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44618675..44631521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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